Optical Fiber Biosensors for Protein Detection: A Review
Proteins play an important role in organisms. The fast and high-accuracy detection of proteins is demanded in various fields, such as healthcare, food safty, and biosecurity, especially in the background of the globally raging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Optical fib...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/9/12/987 |
| _version_ | 1797455631187181568 |
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| author | Shuhan Lyu Zheyu Wu Xinghua Shi Qian Wu |
| author_facet | Shuhan Lyu Zheyu Wu Xinghua Shi Qian Wu |
| author_sort | Shuhan Lyu |
| collection | DOAJ |
| description | Proteins play an important role in organisms. The fast and high-accuracy detection of proteins is demanded in various fields, such as healthcare, food safty, and biosecurity, especially in the background of the globally raging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Optical fiber sensors have great potential for protein detection due to the excellent characteristics of high sensitivity, miniaturization, and capability for remote monitoring. Over the past decades, a large number of structures have been investigated and proposed. This paper begins with an overview of different fiber sensing structures for protein detection according to the fundamental sensing mechanisms. The overview is classified into four sections, including intensity-modulation, phase-modulation, scattering, and fluorescence. In each section, we reviewed the recent advances of fiber protein sensors and compared their performance, such as sensitivity and limit of detection. And then we analyzed the advantages and disadvantages of the four kinds of biosensors. Finally, the paper concludes with the challenges faced and possible future development of optical fiber protein biosensors for further study. |
| first_indexed | 2024-03-09T15:57:04Z |
| format | Article |
| id | doaj.art-12c24ba53a9540928382587df05aae6e |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-09T15:57:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-12c24ba53a9540928382587df05aae6e2023-11-24T17:25:57ZengMDPI AGPhotonics2304-67322022-12-0191298710.3390/photonics9120987Optical Fiber Biosensors for Protein Detection: A ReviewShuhan Lyu0Zheyu Wu1Xinghua Shi2Qian Wu3West Nottingham Academy, 1079 Firetower Road, Colora, MD 21917, USATheory Laboratory, The National Center for Nanoscience and Technology, Beijing 100190, ChinaTheory Laboratory, The National Center for Nanoscience and Technology, Beijing 100190, ChinaDepartment of Mechanical and Aerospace Engineering, University of Missouri, 416 South 6th, Columbia, MI 65211, USAProteins play an important role in organisms. The fast and high-accuracy detection of proteins is demanded in various fields, such as healthcare, food safty, and biosecurity, especially in the background of the globally raging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Optical fiber sensors have great potential for protein detection due to the excellent characteristics of high sensitivity, miniaturization, and capability for remote monitoring. Over the past decades, a large number of structures have been investigated and proposed. This paper begins with an overview of different fiber sensing structures for protein detection according to the fundamental sensing mechanisms. The overview is classified into four sections, including intensity-modulation, phase-modulation, scattering, and fluorescence. In each section, we reviewed the recent advances of fiber protein sensors and compared their performance, such as sensitivity and limit of detection. And then we analyzed the advantages and disadvantages of the four kinds of biosensors. Finally, the paper concludes with the challenges faced and possible future development of optical fiber protein biosensors for further study.https://www.mdpi.com/2304-6732/9/12/987biosensoroptical fiberprotein detection |
| spellingShingle | Shuhan Lyu Zheyu Wu Xinghua Shi Qian Wu Optical Fiber Biosensors for Protein Detection: A Review Photonics biosensor optical fiber protein detection |
| title | Optical Fiber Biosensors for Protein Detection: A Review |
| title_full | Optical Fiber Biosensors for Protein Detection: A Review |
| title_fullStr | Optical Fiber Biosensors for Protein Detection: A Review |
| title_full_unstemmed | Optical Fiber Biosensors for Protein Detection: A Review |
| title_short | Optical Fiber Biosensors for Protein Detection: A Review |
| title_sort | optical fiber biosensors for protein detection a review |
| topic | biosensor optical fiber protein detection |
| url | https://www.mdpi.com/2304-6732/9/12/987 |
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