Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study
INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected wome...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2012-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300005&lng=en&tlng=en |
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| author | Sônia Sampaio Lôpo Paula Matos Oliveira Iuri Usêda Santana Geisa Barbosa Pena Maria Betânia Torrales Rita Elizabeth Mascarenhas Bernardo Galvão-Castro Maria Fernanda Rios Grassi |
| author_facet | Sônia Sampaio Lôpo Paula Matos Oliveira Iuri Usêda Santana Geisa Barbosa Pena Maria Betânia Torrales Rita Elizabeth Mascarenhas Bernardo Galvão-Castro Maria Fernanda Rios Grassi |
| author_sort | Sônia Sampaio Lôpo |
| collection | DOAJ |
| description | INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection. |
| first_indexed | 2024-12-12T09:37:31Z |
| format | Article |
| id | doaj.art-12c251fe515f40b0bfbb9e262b1c5c33 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T09:37:31Z |
| publishDate | 2012-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-12c251fe515f40b0bfbb9e262b1c5c332022-12-22T00:28:40ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492012-06-0145330530810.1590/S0037-86822012000300005S0037-86822012000300005Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional studySônia Sampaio Lôpo0Paula Matos Oliveira1Iuri Usêda Santana2Geisa Barbosa Pena3Maria Betânia Torrales4Rita Elizabeth Mascarenhas5Bernardo Galvão-Castro6Maria Fernanda Rios Grassi7Escola Bahiana de Medicina e Saúde PúblicaEscola Bahiana de Medicina e Saúde PúblicaEscola Bahiana de Medicina e Saúde PúblicaEscola Bahiana de Medicina e Saúde PúblicaUniversidade Federal da BahiaEscola Bahiana de Medicina e Saúde PúblicaEscola Bahiana de Medicina e Saúde PúblicaEscola Bahiana de Medicina e Saúde PúblicaINTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300005&lng=en&tlng=enHTLV-1HPVCarga proviralBrasil |
| spellingShingle | Sônia Sampaio Lôpo Paula Matos Oliveira Iuri Usêda Santana Geisa Barbosa Pena Maria Betânia Torrales Rita Elizabeth Mascarenhas Bernardo Galvão-Castro Maria Fernanda Rios Grassi Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study Revista da Sociedade Brasileira de Medicina Tropical HTLV-1 HPV Carga proviral Brasil |
| title | Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study |
| title_full | Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study |
| title_fullStr | Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study |
| title_full_unstemmed | Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study |
| title_short | Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study |
| title_sort | evidence of a higher prevalence of hpv infection in htlv 1 infected women a cross sectional study |
| topic | HTLV-1 HPV Carga proviral Brasil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000300005&lng=en&tlng=en |
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