Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment
Background: The use of shorter radiotherapy schedules has an economic and logistic advantage for radiotherapy departments, as well as a high degree of patient convenience. The aim of this study is to assess the acute and short-term late toxicities of a hypofractionated radiotherapy schedule with...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2015-01-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/174/179 |
| _version_ | 1828429839518924800 |
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| author | Mona M. Sayed Mohamed I. El-Sayed Alia M. Attia Mostafa E. Abdel-Wanis |
| author_facet | Mona M. Sayed Mohamed I. El-Sayed Alia M. Attia Mostafa E. Abdel-Wanis |
| author_sort | Mona M. Sayed |
| collection | DOAJ |
| description | Background: The use of shorter radiotherapy schedules has an economic and
logistic advantage for radiotherapy departments, as well as a high degree of patient
convenience. The aim of this study is to assess the acute and short-term late toxicities
of a hypofractionated radiotherapy schedule with a concomitant boost.
Methods: We enrolled 57 eligible patients as group A. These patients received 42.5
Gy in 16 fractions of 2.66 Gy each to the whole breast over 3.2 weeks. A concomitant
electron boost of 12 Gy in 16 fractions was also administered which gave an additional
0.75 Gy daily to the lumpectomy area for a total radiation dose of 54.5 Gy. Toxicity
was recorded at three weeks and at three months for this group as well as for a control
group (group B). The control group comprised 76 eligible patients treated conventionally
with 50 Gy to the whole breast over five weeks followed by a sequential electron boost
of 12 Gy in 2 Gy per fraction.
Results: There were no statistically significant differences observed in the incidence
of acute skin toxicity, breast pain, and edema recorded at three weeks or pigmentation
and fibrosis recorded at three months between the two groups (P<0.05). Acceptable
toxicity occurred in both groups with no grade 3 or higher complications. Chest wall
separation was highly correlated with toxicity in both groups (P<0.001) while age showed
no correlation (P>0.05).
Conclusion: The results of this study suggest there are no increased acute and shortterm
late toxicities affiliated with the hypofractionated schedule plus a concomitant boost
as prescribed compared to the conventional fractionation of adjuvant breast radiotherapy.
Large randomized trials and long-term follow-up are needed to confirm these favorable
findings. |
| first_indexed | 2024-12-10T17:40:04Z |
| format | Article |
| id | doaj.art-12c2a6fa01c44643be26efd5c1ca1746 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-10T17:40:04Z |
| publishDate | 2015-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-12c2a6fa01c44643be26efd5c1ca17462022-12-22T01:39:24ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872015-01-01612127Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity AssessmentMona M. Sayed0Mohamed I. El-Sayed1Alia M. Attia2Mostafa E. Abdel-Wanis3Department of Radiation Oncology, South Egypt Cancer Institute, Assiut University, Assiut, EgyptDepartment of Radiation Oncology, South Egypt Cancer Institute, Assiut University, Assiut, EgyptDepartment of Radiation Oncology, South Egypt Cancer Institute, Assiut University, Assiut, EgyptDepartment of Radiation Oncology, South Egypt Cancer Institute, Assiut University, Assiut, EgyptBackground: The use of shorter radiotherapy schedules has an economic and logistic advantage for radiotherapy departments, as well as a high degree of patient convenience. The aim of this study is to assess the acute and short-term late toxicities of a hypofractionated radiotherapy schedule with a concomitant boost. Methods: We enrolled 57 eligible patients as group A. These patients received 42.5 Gy in 16 fractions of 2.66 Gy each to the whole breast over 3.2 weeks. A concomitant electron boost of 12 Gy in 16 fractions was also administered which gave an additional 0.75 Gy daily to the lumpectomy area for a total radiation dose of 54.5 Gy. Toxicity was recorded at three weeks and at three months for this group as well as for a control group (group B). The control group comprised 76 eligible patients treated conventionally with 50 Gy to the whole breast over five weeks followed by a sequential electron boost of 12 Gy in 2 Gy per fraction. Results: There were no statistically significant differences observed in the incidence of acute skin toxicity, breast pain, and edema recorded at three weeks or pigmentation and fibrosis recorded at three months between the two groups (P<0.05). Acceptable toxicity occurred in both groups with no grade 3 or higher complications. Chest wall separation was highly correlated with toxicity in both groups (P<0.001) while age showed no correlation (P>0.05). Conclusion: The results of this study suggest there are no increased acute and shortterm late toxicities affiliated with the hypofractionated schedule plus a concomitant boost as prescribed compared to the conventional fractionation of adjuvant breast radiotherapy. Large randomized trials and long-term follow-up are needed to confirm these favorable findings.http://mejc.sums.ac.ir/index.php/mejc/article/view/174/179Concomitant boostHypofractionated irradiationToxicityBreast cancer |
| spellingShingle | Mona M. Sayed Mohamed I. El-Sayed Alia M. Attia Mostafa E. Abdel-Wanis Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment Middle East Journal of Cancer Concomitant boost Hypofractionated irradiation Toxicity Breast cancer |
| title | Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment |
| title_full | Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment |
| title_fullStr | Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment |
| title_full_unstemmed | Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment |
| title_short | Concurrent Boost with Adjuvant Breast Hypofractionated Radiotherapy and Toxicity Assessment |
| title_sort | concurrent boost with adjuvant breast hypofractionated radiotherapy and toxicity assessment |
| topic | Concomitant boost Hypofractionated irradiation Toxicity Breast cancer |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/174/179 |
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