Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain
Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an au...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnut.2016.00044/full |
| _version_ | 1811239507003965440 |
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| author | Abdoulaye Diane David Pierce Sandra E. Kelly Sharon Sokolik Faye Borthwick Miriam Jacome-Sosa Rabban Mangat JESUS MIGUEL PRADILLO Stuart McRae Allan Megan R. Ruth Catherine J. Field Rebecca Hutcheon Petra Rocic James C. Russell Donna F Vine Spencer D. Proctor |
| author_facet | Abdoulaye Diane David Pierce Sandra E. Kelly Sharon Sokolik Faye Borthwick Miriam Jacome-Sosa Rabban Mangat JESUS MIGUEL PRADILLO Stuart McRae Allan Megan R. Ruth Catherine J. Field Rebecca Hutcheon Petra Rocic James C. Russell Donna F Vine Spencer D. Proctor |
| author_sort | Abdoulaye Diane |
| collection | DOAJ |
| description | Obesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous (cp/cp) spontaneously display the pathophysiology of obesity as well as a metabolic syndrome-like phenotype. Over the years, there have been formidable scientific contributions that have originated from this rat model, much of which has been reviewed extensively up to 2008. The premise of these earlier studies focused on characterizing the pathophysiology of metabolic syndrome-like phenotype that was spontaneously apparent in this model. The purpose of this review is to highlight areas of recent advancement made possible by this model including; emerging appreciation of the ‘thrifty gene’ hypothesis in the context of obesity, the concept of how chronic inflammation may drive obesogenesis, the impact of acute forms of inflammation to the brain and periphery during chronic obesity, the role of dysfunctional insulin metabolism on lipid metabolism and vascular damage, the mechanistic basis for altered vascular function as well as novel parallels between the human condition and the female JCR:LA-cp rat as a model for polycystic ovary disease (PCOS). |
| first_indexed | 2024-04-12T13:00:59Z |
| format | Article |
| id | doaj.art-12c3020793ad4a808e172b39e4c8515f |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T13:00:59Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-12c3020793ad4a808e172b39e4c8515f2022-12-22T03:32:09ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2016-10-01310.3389/fnut.2016.00044213582Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat StrainAbdoulaye Diane0David Pierce1Sandra E. Kelly2Sharon Sokolik3Faye Borthwick4Miriam Jacome-Sosa5Rabban Mangat6JESUS MIGUEL PRADILLO7Stuart McRae Allan8Megan R. Ruth9Catherine J. Field10Rebecca Hutcheon11Petra Rocic12James C. Russell13Donna F Vine14Spencer D. Proctor15University of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversidad Complutense de MadridUniversity of ManchesterUniversity of AlbertaUniversity of AlbertaNew York Medical CollegeNew York Medical CollegeUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaObesity and its metabolic complications have emerged as the epidemic of the new millennia. The use of obese rodent models continues to be a productive component of efforts to understand the concomitant metabolic complications of this disease. In 1978, the JCR:LA-cp rat model was developed with an autosomal recessive corpulent (cp) trait resulting from a premature stop codon in the extracellular domain of the leptin receptor. Rats that are heterozygous for the cp trait are lean-prone, while those that are homozygous (cp/cp) spontaneously display the pathophysiology of obesity as well as a metabolic syndrome-like phenotype. Over the years, there have been formidable scientific contributions that have originated from this rat model, much of which has been reviewed extensively up to 2008. The premise of these earlier studies focused on characterizing the pathophysiology of metabolic syndrome-like phenotype that was spontaneously apparent in this model. The purpose of this review is to highlight areas of recent advancement made possible by this model including; emerging appreciation of the ‘thrifty gene’ hypothesis in the context of obesity, the concept of how chronic inflammation may drive obesogenesis, the impact of acute forms of inflammation to the brain and periphery during chronic obesity, the role of dysfunctional insulin metabolism on lipid metabolism and vascular damage, the mechanistic basis for altered vascular function as well as novel parallels between the human condition and the female JCR:LA-cp rat as a model for polycystic ovary disease (PCOS).http://journal.frontiersin.org/Journal/10.3389/fnut.2016.00044/fullCardiovascular DiseasesInflammationObesitymetabolic syndromeImmune functionpcos |
| spellingShingle | Abdoulaye Diane David Pierce Sandra E. Kelly Sharon Sokolik Faye Borthwick Miriam Jacome-Sosa Rabban Mangat JESUS MIGUEL PRADILLO Stuart McRae Allan Megan R. Ruth Catherine J. Field Rebecca Hutcheon Petra Rocic James C. Russell Donna F Vine Spencer D. Proctor Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain Frontiers in Nutrition Cardiovascular Diseases Inflammation Obesity metabolic syndrome Immune function pcos |
| title | Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain |
| title_full | Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain |
| title_fullStr | Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain |
| title_full_unstemmed | Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain |
| title_short | Mechanisms Of Co-Morbidities Associated With The Metabolic Syndrome: Insights From The JCR:La-Cp Corpulent Rat Strain |
| title_sort | mechanisms of co morbidities associated with the metabolic syndrome insights from the jcr la cp corpulent rat strain |
| topic | Cardiovascular Diseases Inflammation Obesity metabolic syndrome Immune function pcos |
| url | http://journal.frontiersin.org/Journal/10.3389/fnut.2016.00044/full |
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