Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood
Background: Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. Methods: We investigated 186 children who were followed u...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118219300441 |
| _version_ | 1818609056805289984 |
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| author | Chih-Yung Chiu Chia-Hsuan Yang Kuan-Wen Su Ming-Han Tsai Man-Chin Hua Sui-Ling Liao Shen-Hao Lai Li-Chen Chen Kuo-Wei Yeh Jing-Long Huang |
| author_facet | Chih-Yung Chiu Chia-Hsuan Yang Kuan-Wen Su Ming-Han Tsai Man-Chin Hua Sui-Ling Liao Shen-Hao Lai Li-Chen Chen Kuo-Wei Yeh Jing-Long Huang |
| author_sort | Chih-Yung Chiu |
| collection | DOAJ |
| description | Background: Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. Methods: We investigated 186 children who were followed up regularly at the clinic for 4 years in a birth cohort study. The children were classified into three groups: early-onset eczema (<2 years old, n = 55), late-onset eczema (≥2 years old, n = 40), and never eczema groups (n = 91). The associations between the different onsets of eczema and total immunoglobulin E levels, absolute eosinophil count, sensitization to food and inhalant allergens, and allergic outcomes were assessed. Results: A significantly higher prevalence of sensitization to food, especially milk was observed in children with early-onset eczema compared with those without eczema at age 1, 1.5, 2, 3, and 4 years. Furthermore, a significantly higher number of eosinophils was detected in children with early or late-onset eczema at the age of 1.5 years. Both the early- and late-onset eczema were significantly associated with a higher prevalence of allergic rhinitis at age 2, 3, and 4 years, and asthma at age 2. Moreover, the early-onset eczema group showed a significantly increased risk of allergic rhinitis (P = 0.010) and asthma (P = 0.032) at age 4. Conclusion: The children with early-onset eczema (<2 years old) appear to be associated with an increased prevalence of milk sensitization and risk of rhinitis and asthma in early childhood. |
| first_indexed | 2024-12-16T14:52:29Z |
| format | Article |
| id | doaj.art-12c3751b3e8e477b94789c3e67323c06 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-16T14:52:29Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-12c3751b3e8e477b94789c3e67323c062022-12-21T22:27:33ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822020-12-0153610081013Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhoodChih-Yung Chiu0Chia-Hsuan Yang1Kuan-Wen Su2Ming-Han Tsai3Man-Chin Hua4Sui-Ling Liao5Shen-Hao Lai6Li-Chen Chen7Kuo-Wei Yeh8Jing-Long Huang9Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, TaiwanCommunity Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan, TaiwanCommunity Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan, Taiwan.Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan, Taiwan.Background: Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. Methods: We investigated 186 children who were followed up regularly at the clinic for 4 years in a birth cohort study. The children were classified into three groups: early-onset eczema (<2 years old, n = 55), late-onset eczema (≥2 years old, n = 40), and never eczema groups (n = 91). The associations between the different onsets of eczema and total immunoglobulin E levels, absolute eosinophil count, sensitization to food and inhalant allergens, and allergic outcomes were assessed. Results: A significantly higher prevalence of sensitization to food, especially milk was observed in children with early-onset eczema compared with those without eczema at age 1, 1.5, 2, 3, and 4 years. Furthermore, a significantly higher number of eosinophils was detected in children with early or late-onset eczema at the age of 1.5 years. Both the early- and late-onset eczema were significantly associated with a higher prevalence of allergic rhinitis at age 2, 3, and 4 years, and asthma at age 2. Moreover, the early-onset eczema group showed a significantly increased risk of allergic rhinitis (P = 0.010) and asthma (P = 0.032) at age 4. Conclusion: The children with early-onset eczema (<2 years old) appear to be associated with an increased prevalence of milk sensitization and risk of rhinitis and asthma in early childhood.http://www.sciencedirect.com/science/article/pii/S1684118219300441Absolute eosinophil countAsthmaEarly-onset eczemaMilk sensitization |
| spellingShingle | Chih-Yung Chiu Chia-Hsuan Yang Kuan-Wen Su Ming-Han Tsai Man-Chin Hua Sui-Ling Liao Shen-Hao Lai Li-Chen Chen Kuo-Wei Yeh Jing-Long Huang Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood Journal of Microbiology, Immunology and Infection Absolute eosinophil count Asthma Early-onset eczema Milk sensitization |
| title | Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| title_full | Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| title_fullStr | Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| title_full_unstemmed | Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| title_short | Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| title_sort | early onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood |
| topic | Absolute eosinophil count Asthma Early-onset eczema Milk sensitization |
| url | http://www.sciencedirect.com/science/article/pii/S1684118219300441 |
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