Tangent-based volumetric modulated arc therapy for advanced left breast cancer
Abstract Purpose To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advanced left breast cancer needing nodal irradiation. Materials and methods Twen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-018-1167-y |
| _version_ | 1818864144197091328 |
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| author | Pei-Chieh Yu Ching-Jung Wu Hsin-Hua Nien Louis Tak Lui Suzun Shaw Yu-Lun Tsai |
| author_facet | Pei-Chieh Yu Ching-Jung Wu Hsin-Hua Nien Louis Tak Lui Suzun Shaw Yu-Lun Tsai |
| author_sort | Pei-Chieh Yu |
| collection | DOAJ |
| description | Abstract Purpose To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advanced left breast cancer needing nodal irradiation. Materials and methods Twenty-three patients with advanced left breast cancer who had received modified radical mastectomy (MRM) and needed adjuvant radiotherapy including nodal irradiation were assessed. Among 23 radiotherapy treatment plans, 17 plans were designed by using TVMAT technique and 6 plans were designed by using traditional VMAT. The main difference of TVMAT from VMAT was that the area of avoidance sector within specific degrees of angle that had no monitor unit (MU) delivery was used in the arc planning, including a total of 5 sectors in 5 partial arcs. The dosimetries of planning target volume (PTV), right breast, bilateral lungs, and heart between TVMAT and VMAT were compared. Results The conformity index (CI) and homogeneity index (HI) of PTV between two groups were statistically equivalent (CI: 0.98 ± 0.02 and 0.98 ± 0.03, P = 0.431; HI: 0.12 ± 0.03 and 0.11 ± 0.05, P = 0.177), which indicated that the treatment efficacy of the plans regarding TVMAT was compatible with VMAT. However, all neighboring organs at risk (OAR) showed a great percentage of reduction in mean doses (right breast: 53.1%, right lung: 37.7%, left lung: 8.8%, heart: 21.2%) and low dose parameters (V10: right breast: 72.3%, right lung: 86.1%, left lung: 12.5%, heart: 25.1%; V5: right breast: 56.5%, right lung: 28.3%, left lung: 12.7%, heart: 18.2%) by using TVMAT. Conclusion TVMAT greatly decreases the radiation doses delivered to the OAR with maintained therapeutic efficacy. It is highly recommended for treating breast cancer, especially for difficult cases with left side disease needing nodal irradiation. |
| first_indexed | 2024-12-19T10:26:59Z |
| format | Article |
| id | doaj.art-12c60ccab3cb4eca93d7782e8e569c38 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-19T10:26:59Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-12c60ccab3cb4eca93d7782e8e569c382022-12-21T20:25:52ZengBMCRadiation Oncology1748-717X2018-11-0113111010.1186/s13014-018-1167-yTangent-based volumetric modulated arc therapy for advanced left breast cancerPei-Chieh Yu0Ching-Jung Wu1Hsin-Hua Nien2Louis Tak Lui3Suzun Shaw4Yu-Lun Tsai5Department of Radiation Oncology, Cathay General HospitalDepartment of Radiation Oncology, Cathay General HospitalDepartment of Radiation Oncology, Cathay General HospitalDepartment of Radiation Oncology, Cathay General HospitalOncology Treatment Center, Sijhih Cathay General HospitalDepartment of Radiation Oncology, Cathay General HospitalAbstract Purpose To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advanced left breast cancer needing nodal irradiation. Materials and methods Twenty-three patients with advanced left breast cancer who had received modified radical mastectomy (MRM) and needed adjuvant radiotherapy including nodal irradiation were assessed. Among 23 radiotherapy treatment plans, 17 plans were designed by using TVMAT technique and 6 plans were designed by using traditional VMAT. The main difference of TVMAT from VMAT was that the area of avoidance sector within specific degrees of angle that had no monitor unit (MU) delivery was used in the arc planning, including a total of 5 sectors in 5 partial arcs. The dosimetries of planning target volume (PTV), right breast, bilateral lungs, and heart between TVMAT and VMAT were compared. Results The conformity index (CI) and homogeneity index (HI) of PTV between two groups were statistically equivalent (CI: 0.98 ± 0.02 and 0.98 ± 0.03, P = 0.431; HI: 0.12 ± 0.03 and 0.11 ± 0.05, P = 0.177), which indicated that the treatment efficacy of the plans regarding TVMAT was compatible with VMAT. However, all neighboring organs at risk (OAR) showed a great percentage of reduction in mean doses (right breast: 53.1%, right lung: 37.7%, left lung: 8.8%, heart: 21.2%) and low dose parameters (V10: right breast: 72.3%, right lung: 86.1%, left lung: 12.5%, heart: 25.1%; V5: right breast: 56.5%, right lung: 28.3%, left lung: 12.7%, heart: 18.2%) by using TVMAT. Conclusion TVMAT greatly decreases the radiation doses delivered to the OAR with maintained therapeutic efficacy. It is highly recommended for treating breast cancer, especially for difficult cases with left side disease needing nodal irradiation.http://link.springer.com/article/10.1186/s13014-018-1167-yTangent-based volumetric modulated arc therapyBreast cancerRadiation dose |
| spellingShingle | Pei-Chieh Yu Ching-Jung Wu Hsin-Hua Nien Louis Tak Lui Suzun Shaw Yu-Lun Tsai Tangent-based volumetric modulated arc therapy for advanced left breast cancer Radiation Oncology Tangent-based volumetric modulated arc therapy Breast cancer Radiation dose |
| title | Tangent-based volumetric modulated arc therapy for advanced left breast cancer |
| title_full | Tangent-based volumetric modulated arc therapy for advanced left breast cancer |
| title_fullStr | Tangent-based volumetric modulated arc therapy for advanced left breast cancer |
| title_full_unstemmed | Tangent-based volumetric modulated arc therapy for advanced left breast cancer |
| title_short | Tangent-based volumetric modulated arc therapy for advanced left breast cancer |
| title_sort | tangent based volumetric modulated arc therapy for advanced left breast cancer |
| topic | Tangent-based volumetric modulated arc therapy Breast cancer Radiation dose |
| url | http://link.springer.com/article/10.1186/s13014-018-1167-y |
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