Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer
Lipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol content involved in diverse cellular processes. They have been proposed to influence membrane properties and to accommodate receptors within themselves by facilitating their interaction with ligands. Over...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/2/726 |
| _version_ | 1797412227339255808 |
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| author | Michela Codini Mercedes Garcia-Gil Elisabetta Albi |
| author_facet | Michela Codini Mercedes Garcia-Gil Elisabetta Albi |
| author_sort | Michela Codini |
| collection | DOAJ |
| description | Lipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol content involved in diverse cellular processes. They have been proposed to influence membrane properties and to accommodate receptors within themselves by facilitating their interaction with ligands. Over the past decade, technical advances have improved our understanding of lipid rafts as bioactive structures. In this review, we will cover the more recent findings about cholesterol, sphingolipids and lipid rafts located in cellular and nuclear membranes in cancer. Collectively, the data provide insights on the role of lipid rafts as biomolecular targets in cancer with good perspectives for the development of innovative therapeutic strategies. |
| first_indexed | 2024-03-09T04:58:45Z |
| format | Article |
| id | doaj.art-12c678e4ebe7412e88d0bdf48c8d5b00 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:58:45Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-12c678e4ebe7412e88d0bdf48c8d5b002023-12-03T13:01:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122272610.3390/ijms22020726Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in CancerMichela Codini0Mercedes Garcia-Gil1Elisabetta Albi2Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, ItalyDepartment of Biology, University of Pisa, 56127 Pisa, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, ItalyLipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol content involved in diverse cellular processes. They have been proposed to influence membrane properties and to accommodate receptors within themselves by facilitating their interaction with ligands. Over the past decade, technical advances have improved our understanding of lipid rafts as bioactive structures. In this review, we will cover the more recent findings about cholesterol, sphingolipids and lipid rafts located in cellular and nuclear membranes in cancer. Collectively, the data provide insights on the role of lipid rafts as biomolecular targets in cancer with good perspectives for the development of innovative therapeutic strategies.https://www.mdpi.com/1422-0067/22/2/726cholesterolsphingolipidcancerlipid rafttherapeutic target |
| spellingShingle | Michela Codini Mercedes Garcia-Gil Elisabetta Albi Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer International Journal of Molecular Sciences cholesterol sphingolipid cancer lipid raft therapeutic target |
| title | Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer |
| title_full | Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer |
| title_fullStr | Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer |
| title_full_unstemmed | Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer |
| title_short | Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer |
| title_sort | cholesterol and sphingolipid enriched lipid rafts as therapeutic targets in cancer |
| topic | cholesterol sphingolipid cancer lipid raft therapeutic target |
| url | https://www.mdpi.com/1422-0067/22/2/726 |
| work_keys_str_mv | AT michelacodini cholesterolandsphingolipidenrichedlipidraftsastherapeutictargetsincancer AT mercedesgarciagil cholesterolandsphingolipidenrichedlipidraftsastherapeutictargetsincancer AT elisabettaalbi cholesterolandsphingolipidenrichedlipidraftsastherapeutictargetsincancer |