Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy
The objective of the present study was to evaluate the duodenal mucosa of HIV-infected patients during antiretroviral therapy. This was an observational study conducted on HIV-positive patients and a control group. Group 1 comprised 22 HIV-negative individuals while 38 HIV-positive individuals were...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2006-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100013 |
| _version_ | 1828791883768266752 |
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| author | F.R. Machado C. Pagliari H. Caiafa R. Tapajós M.I.S. Duarte |
| author_facet | F.R. Machado C. Pagliari H. Caiafa R. Tapajós M.I.S. Duarte |
| author_sort | F.R. Machado |
| collection | DOAJ |
| description | The objective of the present study was to evaluate the duodenal mucosa of HIV-infected patients during antiretroviral therapy. This was an observational study conducted on HIV-positive patients and a control group. Group 1 comprised 22 HIV-negative individuals while 38 HIV-positive individuals were classified according to the CDC 1993 classification into group 2 (A1 or A2) or group 3 (B2, A3, B3, C2, C3). All subjects were submitted to upper gastrointestinal endoscopy with duodenal biopsies. Qualitative, semi-quantitative and quantitative histological analyses were performed. Results were considered significant when P < 0.05. A higher prevalence of inflammatory infiltrate and eosinophilia was observed in the HIV group, together with a reduction in mucosal CD4+ lymphocyte (L) counts [median (lower-upper quartiles), 12.82 (8.30-20.33), 6.36 (1.75-11.66) and 1.75 (0.87-3.14) in groups 1, 2 and 3, respectively] which was not correlated with disease stage. The extent of CD4+L count reduction was similar in blood and duodenal mucosa. Normal CD8+L and CD45RO+L counts, and normal numbers of macrophages and antigen-presenting cells were also found in the HIV patients. The cytokine pattern did not differ among groups. Tissue HIV, assessed by p24 antigen, correlated with a higher CD45RO+L count (77.0 (61-79.8) and 43.6 (31.7-62.8) in p24+ and p24-, respectively, P = 0.003), and IL-4 positivity (100 and 48.2% in p24+ and p24-, respectively, P = 0.005). The duodenal mucosa of HIV+ patients showed a relatively preserved histological architecture. This finding may be characteristic of a population without opportunistic infections and treated with potent antiretroviral therapy, with a better preservation of the immune status. |
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| id | doaj.art-12c8fdfadac743deb14cd5559f2b0a65 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-12T02:58:34Z |
| publishDate | 2006-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-12c8fdfadac743deb14cd5559f2b0a652022-12-22T00:40:41ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2006-01-0139110711710.1590/S0100-879X2006000100013Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapyF.R. MachadoC. PagliariH. CaiafaR. TapajósM.I.S. DuarteThe objective of the present study was to evaluate the duodenal mucosa of HIV-infected patients during antiretroviral therapy. This was an observational study conducted on HIV-positive patients and a control group. Group 1 comprised 22 HIV-negative individuals while 38 HIV-positive individuals were classified according to the CDC 1993 classification into group 2 (A1 or A2) or group 3 (B2, A3, B3, C2, C3). All subjects were submitted to upper gastrointestinal endoscopy with duodenal biopsies. Qualitative, semi-quantitative and quantitative histological analyses were performed. Results were considered significant when P < 0.05. A higher prevalence of inflammatory infiltrate and eosinophilia was observed in the HIV group, together with a reduction in mucosal CD4+ lymphocyte (L) counts [median (lower-upper quartiles), 12.82 (8.30-20.33), 6.36 (1.75-11.66) and 1.75 (0.87-3.14) in groups 1, 2 and 3, respectively] which was not correlated with disease stage. The extent of CD4+L count reduction was similar in blood and duodenal mucosa. Normal CD8+L and CD45RO+L counts, and normal numbers of macrophages and antigen-presenting cells were also found in the HIV patients. The cytokine pattern did not differ among groups. Tissue HIV, assessed by p24 antigen, correlated with a higher CD45RO+L count (77.0 (61-79.8) and 43.6 (31.7-62.8) in p24+ and p24-, respectively, P = 0.003), and IL-4 positivity (100 and 48.2% in p24+ and p24-, respectively, P = 0.005). The duodenal mucosa of HIV+ patients showed a relatively preserved histological architecture. This finding may be characteristic of a population without opportunistic infections and treated with potent antiretroviral therapy, with a better preservation of the immune status.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100013Intestinal histopathologyCytokinesHuman immunodeficiency virusAcquired immunodeficiency syndromeAntiretroviral therapyCD4+ |
| spellingShingle | F.R. Machado C. Pagliari H. Caiafa R. Tapajós M.I.S. Duarte Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy Brazilian Journal of Medical and Biological Research Intestinal histopathology Cytokines Human immunodeficiency virus Acquired immunodeficiency syndrome Antiretroviral therapy CD4+ |
| title | Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy |
| title_full | Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy |
| title_fullStr | Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy |
| title_full_unstemmed | Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy |
| title_short | Immunopathology of the duodenal mucosa of HIV-positive patients during combined antiretroviral therapy |
| title_sort | immunopathology of the duodenal mucosa of hiv positive patients during combined antiretroviral therapy |
| topic | Intestinal histopathology Cytokines Human immunodeficiency virus Acquired immunodeficiency syndrome Antiretroviral therapy CD4+ |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100013 |
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