Modified Cangfu Daotan decoction ameliorates polycystic ovary syndrome with insulin resistance via NF-κB/LCN-2 signaling pathway in inflammatory microenvironment
This study explored the possible connection between the insulin resistance-targeting protein adipokine lipocalin-2 (LCN-2) and NF-κB signaling pathway in the inflammatory microenvironment in PCOS-IR model rats to determine the pharmacological mechanism of modified Cangfu Daotan decoction (MCDD) inte...
Main Authors: | Shuowen Liu, Yao Zhang, Fang Yang, Jingna Gu, Ruyue Zhang, Yingying Kuang, Wantong Mai, Chengbo Zheng, Yang Yu, Ruling Lu, Lei Zeng, Hongying Cao, Yongling Long |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.975724/full |
Similar Items
-
Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis
by: Yuan Li, et al.
Published: (2023-07-01) -
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome
by: Xiao-lin Jiang, et al.
Published: (2022-11-01) -
Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline
by: Mahdie Kian, et al.
Published: (2022-02-01) -
LCN2: Versatile players in breast cancer
by: Yuxiang Bao, et al.
Published: (2024-02-01) -
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway
by: Chen Shi, et al.
Published: (2024-03-01)