Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity

Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity

Abstract Background Though persons of African descent have one of the widest genetic variability, genetic polymorphisms of drug-metabolising enzymes such as N-Acetyltransferase-2 (NAT2) are understudied. This study aimed to identify prevalent NAT2 single nucleotide polymorphisms (SNPs) and infer the...

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Bibliographic Details
Main Authors: Lilian N. Njagi, Jared O. Mecha, Marianne W Mureithi, Leon E. Otieno, Videlis Nduba
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Medical Genomics
Subjects:
Acetylation
N-acetyltransferase-2 (NAT2)
Genetic variants
Tuberculosis
Pharmacogenetics
Online Access:https://doi.org/10.1186/s12920-023-01788-1

Internet

https://doi.org/10.1186/s12920-023-01788-1

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