Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis
This retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The cohort included 61 pregnant women positive for SARS-CoV-2 infec...
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MDPI AG
2022-09-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/9/1480 |
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| author | Gordana Grgić Anis Cerovac Igor Hudić Antonio Simone Laganà Alessandro Favilli Simone Garzon Vito Chiantera Chrysoula Margioula-Siarkou Azra Hadžimehmedović Amer Mandžić |
| author_facet | Gordana Grgić Anis Cerovac Igor Hudić Antonio Simone Laganà Alessandro Favilli Simone Garzon Vito Chiantera Chrysoula Margioula-Siarkou Azra Hadžimehmedović Amer Mandžić |
| author_sort | Gordana Grgić |
| collection | DOAJ |
| description | This retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The cohort included 61 pregnant women positive for SARS-CoV-2 infection at the time of delivery. Patients were divided into two groups: symptomatic and asymptomatic. We found a significantly higher rate of leukocytosis (<i>p</i> < 0.00078) and lymphopenia (<i>p</i> < 0.0024) in symptomatic women compared with asymptomatic ones. Other laboratory parameters, such as CRP (<i>p</i> = 0.002), AST (<i>p</i> = 0.007), LDH (<i>p</i> = 0.0142), ferritin (<i>p</i> = 0.0036), and D-dimer (<i>p</i> = 0.00124), were also significantly more often increased in the group of symptomatic pregnant women. Overall, symptomatic pregnant women with SARS-CoV-2 infection at the delivery show more often altered laboratory parameters compared with asymptomatic ones; nevertheless, they have a slightly higher but non-significant rate of preterm delivery, cesarean section, as well as lower neonatal birth weight and Apgar score, compared with asymptomatic women. |
| first_indexed | 2024-03-09T23:27:57Z |
| format | Article |
| id | doaj.art-12d01048cc3b4dc8b83d5c807434b15f |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:27:57Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-12d01048cc3b4dc8b83d5c807434b15f2023-11-23T17:13:52ZengMDPI AGJournal of Personalized Medicine2075-44262022-09-01129148010.3390/jpm12091480Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort AnalysisGordana Grgić0Anis Cerovac1Igor Hudić2Antonio Simone Laganà3Alessandro Favilli4Simone Garzon5Vito Chiantera6Chrysoula Margioula-Siarkou7Azra Hadžimehmedović8Amer Mandžić9Clinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, 75000 Tuzla, Bosnia and HerzegovinaSchool of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and HerzegovinaClinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, 75000 Tuzla, Bosnia and HerzegovinaUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyDepartment of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37126 Verona, ItalyUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy2nd Academic Department of Obstetrics and Gynaecology, Hippokration General Hospital, Aristotle University of Thessaloniki, 546 42 Thessaloníki, GreeceClinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, 75000 Tuzla, Bosnia and HerzegovinaClinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, 75000 Tuzla, Bosnia and HerzegovinaThis retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The cohort included 61 pregnant women positive for SARS-CoV-2 infection at the time of delivery. Patients were divided into two groups: symptomatic and asymptomatic. We found a significantly higher rate of leukocytosis (<i>p</i> < 0.00078) and lymphopenia (<i>p</i> < 0.0024) in symptomatic women compared with asymptomatic ones. Other laboratory parameters, such as CRP (<i>p</i> = 0.002), AST (<i>p</i> = 0.007), LDH (<i>p</i> = 0.0142), ferritin (<i>p</i> = 0.0036), and D-dimer (<i>p</i> = 0.00124), were also significantly more often increased in the group of symptomatic pregnant women. Overall, symptomatic pregnant women with SARS-CoV-2 infection at the delivery show more often altered laboratory parameters compared with asymptomatic ones; nevertheless, they have a slightly higher but non-significant rate of preterm delivery, cesarean section, as well as lower neonatal birth weight and Apgar score, compared with asymptomatic women.https://www.mdpi.com/2075-4426/12/9/1480clinical manifestationobstetric outcomesmaternal-neonatal outcomepregnancySARS-CoV-2COVID-19 |
| spellingShingle | Gordana Grgić Anis Cerovac Igor Hudić Antonio Simone Laganà Alessandro Favilli Simone Garzon Vito Chiantera Chrysoula Margioula-Siarkou Azra Hadžimehmedović Amer Mandžić Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis Journal of Personalized Medicine clinical manifestation obstetric outcomes maternal-neonatal outcome pregnancy SARS-CoV-2 COVID-19 |
| title | Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis |
| title_full | Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis |
| title_fullStr | Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis |
| title_full_unstemmed | Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis |
| title_short | Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis |
| title_sort | clinical manifestation and obstetric outcomes in pregnant women with sars cov 2 infection at delivery a retrospective cohort analysis |
| topic | clinical manifestation obstetric outcomes maternal-neonatal outcome pregnancy SARS-CoV-2 COVID-19 |
| url | https://www.mdpi.com/2075-4426/12/9/1480 |
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