Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing
This study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2020-01-01
|
| Series: | Materials Research Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2053-1591/abb154 |
| _version_ | 1797746165144354816 |
|---|---|
| author | Mitra Naeimi Ramtin Tajedin Farmehr Farahmandfar Maryam Naeimi Majid Monajjemi |
| author_facet | Mitra Naeimi Ramtin Tajedin Farmehr Farahmandfar Maryam Naeimi Majid Monajjemi |
| author_sort | Mitra Naeimi |
| collection | DOAJ |
| description | This study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR) spectroscopy were used to characterize the structures. Water uptake percentage and vancomycin release were also measured. The antibacterial activity against Staphylococcus aureus was investigated. According to the results, mean pore diameter (MPD) was decreased by addition of PEG and reached to 1.3 ± 0.5 μ m. On the other hand, 43% decrease in water content of the hydrogels showed along with the incorporation of PEG. The inhibition zone confirmed antibacterial effect of the vancomycin-loaded hydrogels. The porous CS/PVA/PEG hydrogels containing vancomycin could be good candidates to potentially be used as wound dressing. |
| first_indexed | 2024-03-12T15:33:05Z |
| format | Article |
| id | doaj.art-12d30b7bd2bb4550b68e93a5a6e00054 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-12T15:33:05Z |
| publishDate | 2020-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-12d30b7bd2bb4550b68e93a5a6e000542023-08-09T16:19:09ZengIOP PublishingMaterials Research Express2053-15912020-01-017909540110.1088/2053-1591/abb154Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressingMitra Naeimi0https://orcid.org/0000-0002-1268-1777Ramtin Tajedin1Farmehr Farahmandfar2Maryam Naeimi3Majid Monajjemi4Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University , Tehran, IranDepartment of Biomedical Engineering, Central Tehran Branch, Islamic Azad University , Tehran, IranDepartment of Biomedical Engineering, Central Tehran Branch, Islamic Azad University , Tehran, IranDepartment of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic) , Tehran, IranDepartment of Chemical Engineering, Central Tehran Branch, Islamic Azad University , Tehran, IranThis study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR) spectroscopy were used to characterize the structures. Water uptake percentage and vancomycin release were also measured. The antibacterial activity against Staphylococcus aureus was investigated. According to the results, mean pore diameter (MPD) was decreased by addition of PEG and reached to 1.3 ± 0.5 μ m. On the other hand, 43% decrease in water content of the hydrogels showed along with the incorporation of PEG. The inhibition zone confirmed antibacterial effect of the vancomycin-loaded hydrogels. The porous CS/PVA/PEG hydrogels containing vancomycin could be good candidates to potentially be used as wound dressing.https://doi.org/10.1088/2053-1591/abb154poroushydrogelantibacterial |
| spellingShingle | Mitra Naeimi Ramtin Tajedin Farmehr Farahmandfar Maryam Naeimi Majid Monajjemi Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing Materials Research Express porous hydrogel antibacterial |
| title | Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing |
| title_full | Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing |
| title_fullStr | Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing |
| title_full_unstemmed | Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing |
| title_short | Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing |
| title_sort | preparation and characterization of vancomycin loaded chitosan pva peg hydrogels for wound dressing |
| topic | porous hydrogel antibacterial |
| url | https://doi.org/10.1088/2053-1591/abb154 |
| work_keys_str_mv | AT mitranaeimi preparationandcharacterizationofvancomycinloadedchitosanpvapeghydrogelsforwounddressing AT ramtintajedin preparationandcharacterizationofvancomycinloadedchitosanpvapeghydrogelsforwounddressing AT farmehrfarahmandfar preparationandcharacterizationofvancomycinloadedchitosanpvapeghydrogelsforwounddressing AT maryamnaeimi preparationandcharacterizationofvancomycinloadedchitosanpvapeghydrogelsforwounddressing AT majidmonajjemi preparationandcharacterizationofvancomycinloadedchitosanpvapeghydrogelsforwounddressing |