Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

Summary: PBRM1 is frequently mutated in cancers of epithelial origin. How PBRM1 regulates normal epithelial homeostasis, prior to cancer initiation, remains unclear. Here, we show that PBRM1’s gene regulatory roles differ drastically between cell states, leveraging human skin epithelium (epidermis)...

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Bibliographic Details
Main Authors: Patric J. Ho, Junghun Kweon, Laura A. Blumensaadt, Amy E. Neely, Elizabeth Kalika, Daniel B. Leon, Sanghyon Oh, Cooper W.P. Stringer, Sarah M. Lloyd, Ziyou Ren, Xiaomin Bao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Genomics
Subjects:
BAF
SWI/SNF
PBRM1
PIAS1
SUMO
progenitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X23003154

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