Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality
Low overall survival (OS) still is a major concern of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is affected by many individual and environmental factors. In this study, we retrospectively evaluated the association of donor and recipient individual factors with the overall...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-02-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8492 |
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| author | Pooya Eslampour Sayeh Parkhideh Mahshid Mehdizadeh Samira Karami Elham Roshandel Hossein Bonakchi Abbas Hajifathali |
| author_facet | Pooya Eslampour Sayeh Parkhideh Mahshid Mehdizadeh Samira Karami Elham Roshandel Hossein Bonakchi Abbas Hajifathali |
| author_sort | Pooya Eslampour |
| collection | DOAJ |
| description | Low overall survival (OS) still is a major concern of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is affected by many individual and environmental factors. In this study, we retrospectively evaluated the association of donor and recipient individual factors with the overall survival of 206 patients who underwent allo-HSCT. Donor and recipient prognostic factors consisted of donor and recipient age, donor-recipient gender status, recipient body mass index (BMI), underlying disease, recipient cytomegalovirus (CMV) serostatus, and time from diagnosis to transplant (DTT) were included in the overall survival analysis. In univariable analysis, recipient age, donor-recipient gender status, underlying disease, recipient CMV serostatus, and DTT were significantly associated with the OS. The hazard of death in patients with DTT less than 14 months was 38% lower than those with a DTT higher than 14 months (P=0.06). Multivariate analysis showed that patients with aplastic anemia (HR=3.58; P=0.11) and Hodgkin’s disease (HR=3.89; P=0.11) have a much lower survival than unclassified diseases. Moreover, patients with acute myeloid leukemia and acute lymphoblastic leukemia showed better outcomes compared to the unclassified group. The donor and patient characteristics such as age, CMV serostatus, underlying disease, and time from diagnosis to transplantation could influence the overall survival of patients after allo-HSCT. |
| first_indexed | 2024-12-14T07:03:12Z |
| format | Article |
| id | doaj.art-12d531d3cbfc46e6aea42e5f63673b41 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-14T07:03:12Z |
| publishDate | 2021-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-12d531d3cbfc46e6aea42e5f63673b412022-12-21T23:12:21ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942021-02-0159110.18502/acta.v59i1.5400Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or RealityPooya Eslampour0Sayeh Parkhideh1Mahshid Mehdizadeh2Samira Karami3Elham Roshandel4Hossein Bonakchi5Abbas Hajifathali6Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranHematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Low overall survival (OS) still is a major concern of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is affected by many individual and environmental factors. In this study, we retrospectively evaluated the association of donor and recipient individual factors with the overall survival of 206 patients who underwent allo-HSCT. Donor and recipient prognostic factors consisted of donor and recipient age, donor-recipient gender status, recipient body mass index (BMI), underlying disease, recipient cytomegalovirus (CMV) serostatus, and time from diagnosis to transplant (DTT) were included in the overall survival analysis. In univariable analysis, recipient age, donor-recipient gender status, underlying disease, recipient CMV serostatus, and DTT were significantly associated with the OS. The hazard of death in patients with DTT less than 14 months was 38% lower than those with a DTT higher than 14 months (P=0.06). Multivariate analysis showed that patients with aplastic anemia (HR=3.58; P=0.11) and Hodgkin’s disease (HR=3.89; P=0.11) have a much lower survival than unclassified diseases. Moreover, patients with acute myeloid leukemia and acute lymphoblastic leukemia showed better outcomes compared to the unclassified group. The donor and patient characteristics such as age, CMV serostatus, underlying disease, and time from diagnosis to transplantation could influence the overall survival of patients after allo-HSCT.https://acta.tums.ac.ir/index.php/acta/article/view/8492Individual factorsAllogeneic hematopoietic stem cell transplantation (allo-HSCT)Overall survival |
| spellingShingle | Pooya Eslampour Sayeh Parkhideh Mahshid Mehdizadeh Samira Karami Elham Roshandel Hossein Bonakchi Abbas Hajifathali Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality Acta Medica Iranica Individual factors Allogeneic hematopoietic stem cell transplantation (allo-HSCT) Overall survival |
| title | Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality |
| title_full | Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality |
| title_fullStr | Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality |
| title_full_unstemmed | Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality |
| title_short | Donor and Recipient Individual Factors as Predictive Markers of Overall Survival After Allogeneic Hematopoietic Stem Cell Transplantation; Dream or Reality |
| title_sort | donor and recipient individual factors as predictive markers of overall survival after allogeneic hematopoietic stem cell transplantation dream or reality |
| topic | Individual factors Allogeneic hematopoietic stem cell transplantation (allo-HSCT) Overall survival |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8492 |
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