Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang
Background. Transcranial sonography (TCS) is a noninvasive test that can reveal structural changes in the substantia nigra (SN) in Parkinson’s disease (PD). The purpose of this study was to investigate the relationship between SN signatures and clinical features in PD patients in a multiethnic regio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2023/8867546 |
| _version_ | 1827082263509073920 |
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| author | Rurui Wei Yan Zhang Peishan Li Zeheng Xu La Zhang Yan He Qinfen Wu Youcai Shi Yang Yuan Abudula Aisha |
| author_facet | Rurui Wei Yan Zhang Peishan Li Zeheng Xu La Zhang Yan He Qinfen Wu Youcai Shi Yang Yuan Abudula Aisha |
| author_sort | Rurui Wei |
| collection | DOAJ |
| description | Background. Transcranial sonography (TCS) is a noninvasive test that can reveal structural changes in the substantia nigra (SN) in Parkinson’s disease (PD). The purpose of this study was to investigate the relationship between SN signatures and clinical features in PD patients in a multiethnic region of China. Methods. A total of 147 patients with PD were included in the study, and all of whom had underwent a TCS examination. Clinical information was collected from PD patients, and motor and nonmotor symptoms were assessed using assessment scales. Results. There were differences in the substantia nigra hyperechogenicity (SNH) area between age of onset, visual hallucinations (VH), and UPDRS3.0 II scores (P < 0.05), patients with late onset PD had a greater SNH area than early onset (0.326 ± 0.352 vs. 0.171 ± 0.194), and PD patients presenting with VH had a greater SNH area than those without hallucinations (0.508 ± 0.670 vs. 0.278 ± 0.659), and further multifactorial analysis showed that a high SNH area was an independent risk factor for development of VH. The area under the ROC curve for predicting VH from the SNH area in PD patients was 0.609 (95% CI: 0.444–0.774). There was a positive correlation between the SNH area and UPDRS3.0-II scores, but further multifactorial analysis showed that SNH was not an independent predictor of the UPDRS3.0-II score. Conclusion. A high SNH area is an independent risk factor for development of VH, there is a positive correlation between the SNH area and UPDRS3.0 II score, and TCS has guiding significance in predicting clinical VH symptoms and activities of daily living in PD patients. |
| first_indexed | 2024-03-13T06:37:44Z |
| format | Article |
| id | doaj.art-12d5627fdd4c4a4cb10838e3d9feb4be |
| institution | Directory Open Access Journal |
| issn | 2042-0080 |
| language | English |
| last_indexed | 2025-03-20T03:30:28Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj.art-12d5627fdd4c4a4cb10838e3d9feb4be2024-10-03T07:06:28ZengHindawi LimitedParkinson's Disease2042-00802023-01-01202310.1155/2023/8867546Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in XinjiangRurui Wei0Yan Zhang1Peishan Li2Zeheng Xu3La Zhang4Yan He5Qinfen Wu6Youcai Shi7Yang Yuan8Abudula Aisha9The Second Affiliated Hospital of Xinjiang Medical UniversityDepartment of Epidemiology and Health StatisticsThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityThe Second Affiliated Hospital of Xinjiang Medical UniversityBackground. Transcranial sonography (TCS) is a noninvasive test that can reveal structural changes in the substantia nigra (SN) in Parkinson’s disease (PD). The purpose of this study was to investigate the relationship between SN signatures and clinical features in PD patients in a multiethnic region of China. Methods. A total of 147 patients with PD were included in the study, and all of whom had underwent a TCS examination. Clinical information was collected from PD patients, and motor and nonmotor symptoms were assessed using assessment scales. Results. There were differences in the substantia nigra hyperechogenicity (SNH) area between age of onset, visual hallucinations (VH), and UPDRS3.0 II scores (P < 0.05), patients with late onset PD had a greater SNH area than early onset (0.326 ± 0.352 vs. 0.171 ± 0.194), and PD patients presenting with VH had a greater SNH area than those without hallucinations (0.508 ± 0.670 vs. 0.278 ± 0.659), and further multifactorial analysis showed that a high SNH area was an independent risk factor for development of VH. The area under the ROC curve for predicting VH from the SNH area in PD patients was 0.609 (95% CI: 0.444–0.774). There was a positive correlation between the SNH area and UPDRS3.0-II scores, but further multifactorial analysis showed that SNH was not an independent predictor of the UPDRS3.0-II score. Conclusion. A high SNH area is an independent risk factor for development of VH, there is a positive correlation between the SNH area and UPDRS3.0 II score, and TCS has guiding significance in predicting clinical VH symptoms and activities of daily living in PD patients.http://dx.doi.org/10.1155/2023/8867546 |
| spellingShingle | Rurui Wei Yan Zhang Peishan Li Zeheng Xu La Zhang Yan He Qinfen Wu Youcai Shi Yang Yuan Abudula Aisha Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang Parkinson's Disease |
| title | Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang |
| title_full | Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang |
| title_fullStr | Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang |
| title_full_unstemmed | Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang |
| title_short | Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson’s Disease in Xinjiang |
| title_sort | substantia nigra echogenicity signal correlated with clinical features in patients with parkinson s disease in xinjiang |
| url | http://dx.doi.org/10.1155/2023/8867546 |
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