Targeting heat shock proteins to modulate α-synuclein toxicity
Parkinson’s disease is a slowly progressive neurodegenerative disorder typically characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta, and the intraneuronal deposition of insoluble protein aggregates chiefly comprised of α-synuclein. Patients experience debilit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-01-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/1756285613493469 |
| _version_ | 1817976529061150720 |
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| author | Daryl Rhys Jones Simon Moussaud Pamela McLean |
| author_facet | Daryl Rhys Jones Simon Moussaud Pamela McLean |
| author_sort | Daryl Rhys Jones |
| collection | DOAJ |
| description | Parkinson’s disease is a slowly progressive neurodegenerative disorder typically characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta, and the intraneuronal deposition of insoluble protein aggregates chiefly comprised of α-synuclein. Patients experience debilitating symptoms including bradykinesia, rigidity and postural instability. No curative treatment currently exists and therapeutic strategies are restricted to symptomatic treatment only. Over the past decade a class of molecular chaperones called the heat shock proteins has emerged as a potentially promising therapeutic target. Heat shock proteins aid in the folding and refolding of proteins, and target denatured proteins to degradation systems. By targeting heat shock proteins through various means including overexpression and pharmacological enhancement, researchers have shown that α-synuclein aggregation and its associated cytotoxicity can be therapeutically modulated in an array of cell and animal models. This review highlights the relevant progress in this field and discusses the relevance of heat shock proteins as therapeutic modulators of α-synuclein toxicity to the rapidly evolving understanding of Parkinson’s disease pathogenesis. |
| first_indexed | 2024-04-13T22:04:47Z |
| format | Article |
| id | doaj.art-12d586b39b0d462c898d7c1ad94da31c |
| institution | Directory Open Access Journal |
| issn | 1756-2856 1756-2864 |
| language | English |
| last_indexed | 2024-04-13T22:04:47Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-12d586b39b0d462c898d7c1ad94da31c2022-12-22T02:27:58ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28561756-28642014-01-01710.1177/1756285613493469Targeting heat shock proteins to modulate α-synuclein toxicityDaryl Rhys JonesSimon MoussaudPamela McLeanParkinson’s disease is a slowly progressive neurodegenerative disorder typically characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta, and the intraneuronal deposition of insoluble protein aggregates chiefly comprised of α-synuclein. Patients experience debilitating symptoms including bradykinesia, rigidity and postural instability. No curative treatment currently exists and therapeutic strategies are restricted to symptomatic treatment only. Over the past decade a class of molecular chaperones called the heat shock proteins has emerged as a potentially promising therapeutic target. Heat shock proteins aid in the folding and refolding of proteins, and target denatured proteins to degradation systems. By targeting heat shock proteins through various means including overexpression and pharmacological enhancement, researchers have shown that α-synuclein aggregation and its associated cytotoxicity can be therapeutically modulated in an array of cell and animal models. This review highlights the relevant progress in this field and discusses the relevance of heat shock proteins as therapeutic modulators of α-synuclein toxicity to the rapidly evolving understanding of Parkinson’s disease pathogenesis.https://doi.org/10.1177/1756285613493469 |
| spellingShingle | Daryl Rhys Jones Simon Moussaud Pamela McLean Targeting heat shock proteins to modulate α-synuclein toxicity Therapeutic Advances in Neurological Disorders |
| title | Targeting heat shock proteins to modulate α-synuclein toxicity |
| title_full | Targeting heat shock proteins to modulate α-synuclein toxicity |
| title_fullStr | Targeting heat shock proteins to modulate α-synuclein toxicity |
| title_full_unstemmed | Targeting heat shock proteins to modulate α-synuclein toxicity |
| title_short | Targeting heat shock proteins to modulate α-synuclein toxicity |
| title_sort | targeting heat shock proteins to modulate α synuclein toxicity |
| url | https://doi.org/10.1177/1756285613493469 |
| work_keys_str_mv | AT darylrhysjones targetingheatshockproteinstomodulateasynucleintoxicity AT simonmoussaud targetingheatshockproteinstomodulateasynucleintoxicity AT pamelamclean targetingheatshockproteinstomodulateasynucleintoxicity |