Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration
Non-coding RNAs (ncRNAs), which are usually considered not to encode proteins, are widely involved in important activities including signal transduction and cell proliferation. However, recent studies have shown that small peptides encoded by ncRNAs (SPENs) have important roles in the development of...
| Main Authors: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Frontiers Media S.A.
2024-09-01
|
| Colecção: | Frontiers in Pharmacology |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1442196/full |
| _version_ | 1827113846969466880 |
|---|---|
| author | Jie Liu Jie Liu Xiyue Chang Xiyue Chang Laeeqa Manji Zhijie Xu Wan’an Xiao |
| author_facet | Jie Liu Jie Liu Xiyue Chang Xiyue Chang Laeeqa Manji Zhijie Xu Wan’an Xiao |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Non-coding RNAs (ncRNAs), which are usually considered not to encode proteins, are widely involved in important activities including signal transduction and cell proliferation. However, recent studies have shown that small peptides encoded by ncRNAs (SPENs) have important roles in the development of malignant tumors. Some SPENs participate in the regulation of skeleton reorganization, intercellular adhesion, signaling and other processes of tumor cells, with effects on the invasive and migratory abilities of the cells. Therefore, SPENs have potential applications as therapeutic targets and biomarkers of malignant tumors. Invasion and migration of malignant tumor cells are the main reasons for poor prognosis of cancer patients and represent the most challenging aspects of treatment of malignant tumors. Currently, the main treatments for tumors include surgery, radiotherapy, targeted drug therapy. Surgery, however, is reserved for early stages of cancer and carries risks and costs. Radiotherapy and targeted therapy have serious side effects. This review describes the mechanisms of SPENs and their roles in tumor invasion and migration, with the aim of providing new targets for tumor diagnosis and treatment. |
| first_indexed | 2025-03-20T11:52:28Z |
| format | Article |
| id | doaj.art-12d6d0a360e44519844f8a01de7c1b51 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2025-03-20T11:52:28Z |
| publishDate | 2024-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-12d6d0a360e44519844f8a01de7c1b512024-09-16T04:42:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-09-011510.3389/fphar.2024.14421961442196Roles of small peptides encoded by non-coding RNAs in tumor invasion and migrationJie Liu0Jie Liu1Xiyue Chang2Xiyue Chang3Laeeqa Manji4Zhijie Xu5Wan’an Xiao6Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaNon-coding RNAs (ncRNAs), which are usually considered not to encode proteins, are widely involved in important activities including signal transduction and cell proliferation. However, recent studies have shown that small peptides encoded by ncRNAs (SPENs) have important roles in the development of malignant tumors. Some SPENs participate in the regulation of skeleton reorganization, intercellular adhesion, signaling and other processes of tumor cells, with effects on the invasive and migratory abilities of the cells. Therefore, SPENs have potential applications as therapeutic targets and biomarkers of malignant tumors. Invasion and migration of malignant tumor cells are the main reasons for poor prognosis of cancer patients and represent the most challenging aspects of treatment of malignant tumors. Currently, the main treatments for tumors include surgery, radiotherapy, targeted drug therapy. Surgery, however, is reserved for early stages of cancer and carries risks and costs. Radiotherapy and targeted therapy have serious side effects. This review describes the mechanisms of SPENs and their roles in tumor invasion and migration, with the aim of providing new targets for tumor diagnosis and treatment.https://www.frontiersin.org/articles/10.3389/fphar.2024.1442196/fullnon-coding RNAtumorsmall peptideinvasionmigration |
| spellingShingle | Jie Liu Jie Liu Xiyue Chang Xiyue Chang Laeeqa Manji Zhijie Xu Wan’an Xiao Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration Frontiers in Pharmacology non-coding RNA tumor small peptide invasion migration |
| title | Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration |
| title_full | Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration |
| title_fullStr | Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration |
| title_full_unstemmed | Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration |
| title_short | Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration |
| title_sort | roles of small peptides encoded by non coding rnas in tumor invasion and migration |
| topic | non-coding RNA tumor small peptide invasion migration |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1442196/full |
| work_keys_str_mv | AT jieliu rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT jieliu rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT xiyuechang rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT xiyuechang rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT laeeqamanji rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT zhijiexu rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration AT wananxiao rolesofsmallpeptidesencodedbynoncodingrnasintumorinvasionandmigration |