Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options
<i>Helicobacter pylori</i> is a gastric pathogen that infects nearly half of the global population and is recognized as a group 1 carcinogen by the Word Health Organization. The global rise in antibiotic resistance has increased clinical challenges in treating <i>H. pylori</i>...
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Format: | Article |
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MDPI AG
2023-07-01
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Series: | Antibiotics |
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Online Access: | https://www.mdpi.com/2079-6382/12/8/1260 |
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author | Yasmine Elshenawi Shuai Hu Skander Hathroubi |
author_facet | Yasmine Elshenawi Shuai Hu Skander Hathroubi |
author_sort | Yasmine Elshenawi |
collection | DOAJ |
description | <i>Helicobacter pylori</i> is a gastric pathogen that infects nearly half of the global population and is recognized as a group 1 carcinogen by the Word Health Organization. The global rise in antibiotic resistance has increased clinical challenges in treating <i>H. pylori</i> infections. Biofilm growth has been proposed to contribute to <i>H. pylori’s chronic</i> colonization of the host stomach, treatment failures, and the eventual development of gastric diseases. Several components of <i>H. pylori</i> have been identified to promote biofilm growth, and several of these may also facilitate antibiotic tolerance, including the extracellular matrix, outer membrane proteins, shifted morphology, modulated metabolism, efflux pumps, and virulence factors. Recent developments in therapeutic approaches targeting <i>H. pylori</i> biofilm have shown that synthetic compounds, such as small molecule drugs and plant-derived compounds, are effective at eradicating <i>H. pylori</i> biofilms. These combined topics highlight the necessity for biofilm-based research in <i>H. pylori</i>, to improve current <i>H. pylori</i>-targeted therapeutic approaches and alleviate relative public health burden. In this review we discuss recent discoveries that have decoded the life cycle of <i>H. pylori</i> biofilms and current biofilm-targeted treatment strategies. |
first_indexed | 2024-03-11T00:10:12Z |
format | Article |
id | doaj.art-12d6fdf746424d0fbd40c615e14764ad |
institution | Directory Open Access Journal |
issn | 2079-6382 |
language | English |
last_indexed | 2024-03-11T00:10:12Z |
publishDate | 2023-07-01 |
publisher | MDPI AG |
record_format | Article |
series | Antibiotics |
spelling | doaj.art-12d6fdf746424d0fbd40c615e14764ad2023-11-18T23:59:07ZengMDPI AGAntibiotics2079-63822023-07-01128126010.3390/antibiotics12081260Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment OptionsYasmine Elshenawi0Shuai Hu1Skander Hathroubi2Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064, USADepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064, USASpartha Medical, CRBS 1 Rue Eugène Boeckel, 67000 Strasbourg, France<i>Helicobacter pylori</i> is a gastric pathogen that infects nearly half of the global population and is recognized as a group 1 carcinogen by the Word Health Organization. The global rise in antibiotic resistance has increased clinical challenges in treating <i>H. pylori</i> infections. Biofilm growth has been proposed to contribute to <i>H. pylori’s chronic</i> colonization of the host stomach, treatment failures, and the eventual development of gastric diseases. Several components of <i>H. pylori</i> have been identified to promote biofilm growth, and several of these may also facilitate antibiotic tolerance, including the extracellular matrix, outer membrane proteins, shifted morphology, modulated metabolism, efflux pumps, and virulence factors. Recent developments in therapeutic approaches targeting <i>H. pylori</i> biofilm have shown that synthetic compounds, such as small molecule drugs and plant-derived compounds, are effective at eradicating <i>H. pylori</i> biofilms. These combined topics highlight the necessity for biofilm-based research in <i>H. pylori</i>, to improve current <i>H. pylori</i>-targeted therapeutic approaches and alleviate relative public health burden. In this review we discuss recent discoveries that have decoded the life cycle of <i>H. pylori</i> biofilms and current biofilm-targeted treatment strategies.https://www.mdpi.com/2079-6382/12/8/1260<i>Helicobacter pylori</i>biofilmsplanktonicantibiotic resistanceextra polymeric substanceabiotic/biotic adhesion |
spellingShingle | Yasmine Elshenawi Shuai Hu Skander Hathroubi Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options Antibiotics <i>Helicobacter pylori</i> biofilms planktonic antibiotic resistance extra polymeric substance abiotic/biotic adhesion |
title | Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options |
title_full | Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options |
title_fullStr | Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options |
title_full_unstemmed | Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options |
title_short | Biofilm of <i>Helicobacter pylori</i>: Life Cycle, Features, and Treatment Options |
title_sort | biofilm of i helicobacter pylori i life cycle features and treatment options |
topic | <i>Helicobacter pylori</i> biofilms planktonic antibiotic resistance extra polymeric substance abiotic/biotic adhesion |
url | https://www.mdpi.com/2079-6382/12/8/1260 |
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