Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review
Introduction: Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling early identification and intervention. This review...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Osteoarthritis and Cartilage Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913123000523 |
| _version_ | 1827856063696732160 |
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| author | Oliver O'Sullivan Peter Ladlow Kat Steiner Dahria Kuyser Omaima Ali Joanne Stocks Ana M. Valdes Alexander N. Bennett Stefan Kluzek |
| author_facet | Oliver O'Sullivan Peter Ladlow Kat Steiner Dahria Kuyser Omaima Ali Joanne Stocks Ana M. Valdes Alexander N. Bennett Stefan Kluzek |
| author_sort | Oliver O'Sullivan |
| collection | DOAJ |
| description | Introduction: Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling early identification and intervention. This review aims to describe imaging features associated with structural changes or symptoms at least one year following injury. Methodology: A systematic review was conducted using PRISMA guidance, prospectively registered on PROSPERO (CRD42022371838). Three independent reviewers screened titles and abstracts, followed by full-texts, performed data extraction, and risk of bias assessments (Newcastle-Ottawa Scale). Inclusion criteria included imaging studies involving human participants aged 18–45 who had sustained a significant knee injury at least a year previously. A narrative synthesis was performed using synthesis without meta-analysis methodology. Results: Six electronic databases and conference proceedings were searched, identifying 11 studies involving 776 participants. All studies included participants suffering an anterior cruciate ligament (ACL) injury and utilised MRI. Different, and not directly comparable, techniques were used. MRI features could be broadly divided into structural, including joint position and morphology, and compositional. Promising biomarkers for diagnosing and predicting osteoarthritis include T1rho and T2 relaxation time techniques, bone morphology changes and radiomic modelling. Discussion: As early as 12 months after injury, differences in tibia position, bone morphology, presence of effusion and synovitis, and cartilage/subchondral bone composition can be detected, some of which are linked with worse patient-reported or radiological progression. Standardisation, including MR strength, position, sequence, scoring and comparators, is required to utilise clinical and research OA imaging biomarkers fully. |
| first_indexed | 2024-03-12T12:19:20Z |
| format | Article |
| id | doaj.art-12d79f359eca4e13af81ab8b548762cb |
| institution | Directory Open Access Journal |
| issn | 2665-9131 |
| language | English |
| last_indexed | 2024-03-12T12:19:20Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj.art-12d79f359eca4e13af81ab8b548762cb2023-08-30T05:54:49ZengElsevierOsteoarthritis and Cartilage Open2665-91312023-09-0153100385Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic reviewOliver O'Sullivan0Peter Ladlow1Kat Steiner2Dahria Kuyser3Omaima Ali4Joanne Stocks5Ana M. Valdes6Alexander N. Bennett7Stefan Kluzek8Academic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK; Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK; Corresponding author. Academic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK; Department of Health, University of Bath, Bath, UKBodleian Health Care Libraries, University of Oxford, Oxford, UKUniversity of Oxford, Oxford, UKUniversity of Oxford, Oxford, UKAcademic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UKNottingham NIHR Biomedical Research Centre, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK; Department of Twin Research & Genetic Epidemiology, King's College London, London, UKNational Heart and Lung Institute, Imperial College London, London, UKAcademic Unit of Injury, Recovery and Inflammation Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Nottingham, Nottingham, UKIntroduction: Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling early identification and intervention. This review aims to describe imaging features associated with structural changes or symptoms at least one year following injury. Methodology: A systematic review was conducted using PRISMA guidance, prospectively registered on PROSPERO (CRD42022371838). Three independent reviewers screened titles and abstracts, followed by full-texts, performed data extraction, and risk of bias assessments (Newcastle-Ottawa Scale). Inclusion criteria included imaging studies involving human participants aged 18–45 who had sustained a significant knee injury at least a year previously. A narrative synthesis was performed using synthesis without meta-analysis methodology. Results: Six electronic databases and conference proceedings were searched, identifying 11 studies involving 776 participants. All studies included participants suffering an anterior cruciate ligament (ACL) injury and utilised MRI. Different, and not directly comparable, techniques were used. MRI features could be broadly divided into structural, including joint position and morphology, and compositional. Promising biomarkers for diagnosing and predicting osteoarthritis include T1rho and T2 relaxation time techniques, bone morphology changes and radiomic modelling. Discussion: As early as 12 months after injury, differences in tibia position, bone morphology, presence of effusion and synovitis, and cartilage/subchondral bone composition can be detected, some of which are linked with worse patient-reported or radiological progression. Standardisation, including MR strength, position, sequence, scoring and comparators, is required to utilise clinical and research OA imaging biomarkers fully.http://www.sciencedirect.com/science/article/pii/S2665913123000523BiomarkersPost-traumatic osteoarthritisOAChronicMRI |
| spellingShingle | Oliver O'Sullivan Peter Ladlow Kat Steiner Dahria Kuyser Omaima Ali Joanne Stocks Ana M. Valdes Alexander N. Bennett Stefan Kluzek Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review Osteoarthritis and Cartilage Open Biomarkers Post-traumatic osteoarthritis OA Chronic MRI |
| title | Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review |
| title_full | Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review |
| title_fullStr | Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review |
| title_full_unstemmed | Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review |
| title_short | Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review |
| title_sort | knee mri biomarkers associated with structural functional and symptomatic changes at least a year from acl injury a systematic review |
| topic | Biomarkers Post-traumatic osteoarthritis OA Chronic MRI |
| url | http://www.sciencedirect.com/science/article/pii/S2665913123000523 |
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