Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade.
Specification of the myriad of unique neuronal subtypes found in the nervous system depends upon spatiotemporal cues and terminal selector gene cascades, often acting in sequential combinatorial codes to determine final cell fate. However, a specific neuronal cell subtype can often be generated in d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-05-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.1002450 |
| _version_ | 1831524034792128512 |
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| author | Hugo Gabilondo Johannes Stratmann Irene Rubio-Ferrera Irene Millán-Crespo Patricia Contero-García Shahrzad Bahrampour Stefan Thor Stefan Thor Jonathan Benito-Sipos |
| author_facet | Hugo Gabilondo Johannes Stratmann Irene Rubio-Ferrera Irene Millán-Crespo Patricia Contero-García Shahrzad Bahrampour Stefan Thor Stefan Thor Jonathan Benito-Sipos |
| author_sort | Hugo Gabilondo |
| collection | DOAJ |
| description | Specification of the myriad of unique neuronal subtypes found in the nervous system depends upon spatiotemporal cues and terminal selector gene cascades, often acting in sequential combinatorial codes to determine final cell fate. However, a specific neuronal cell subtype can often be generated in different parts of the nervous system and at different stages, indicating that different spatiotemporal cues can converge on the same terminal selectors to thereby generate a similar cell fate. However, the regulatory mechanisms underlying such convergence are poorly understood. The Nplp1 neuropeptide neurons in the Drosophila ventral nerve cord can be subdivided into the thoracic-ventral Tv1 neurons and the dorsal-medial dAp neurons. The activation of Nplp1 in Tv1 and dAp neurons depends upon the same terminal selector cascade: col>ap/eya>dimm>Nplp1. However, Tv1 and dAp neurons are generated by different neural progenitors (neuroblasts) with different spatiotemporal appearance. Here, we find that the same terminal selector cascade is triggered by Kr/pdm>grn in dAp neurons, but by Antp/hth/exd/lbe/cas in Tv1 neurons. Hence, two different spatiotemporal combinations can funnel into a common downstream terminal selector cascade to determine a highly related cell fate. |
| first_indexed | 2024-12-16T06:41:55Z |
| format | Article |
| id | doaj.art-12d7be2e87674952bc12dcb113dd319f |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-16T06:41:55Z |
| publishDate | 2016-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-12d7be2e87674952bc12dcb113dd319f2022-12-21T22:40:39ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852016-05-01145e100245010.1371/journal.pbio.1002450Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade.Hugo GabilondoJohannes StratmannIrene Rubio-FerreraIrene Millán-CrespoPatricia Contero-GarcíaShahrzad BahrampourStefan ThorStefan ThorJonathan Benito-SiposSpecification of the myriad of unique neuronal subtypes found in the nervous system depends upon spatiotemporal cues and terminal selector gene cascades, often acting in sequential combinatorial codes to determine final cell fate. However, a specific neuronal cell subtype can often be generated in different parts of the nervous system and at different stages, indicating that different spatiotemporal cues can converge on the same terminal selectors to thereby generate a similar cell fate. However, the regulatory mechanisms underlying such convergence are poorly understood. The Nplp1 neuropeptide neurons in the Drosophila ventral nerve cord can be subdivided into the thoracic-ventral Tv1 neurons and the dorsal-medial dAp neurons. The activation of Nplp1 in Tv1 and dAp neurons depends upon the same terminal selector cascade: col>ap/eya>dimm>Nplp1. However, Tv1 and dAp neurons are generated by different neural progenitors (neuroblasts) with different spatiotemporal appearance. Here, we find that the same terminal selector cascade is triggered by Kr/pdm>grn in dAp neurons, but by Antp/hth/exd/lbe/cas in Tv1 neurons. Hence, two different spatiotemporal combinations can funnel into a common downstream terminal selector cascade to determine a highly related cell fate.https://doi.org/10.1371/journal.pbio.1002450 |
| spellingShingle | Hugo Gabilondo Johannes Stratmann Irene Rubio-Ferrera Irene Millán-Crespo Patricia Contero-García Shahrzad Bahrampour Stefan Thor Stefan Thor Jonathan Benito-Sipos Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. PLoS Biology |
| title | Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. |
| title_full | Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. |
| title_fullStr | Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. |
| title_full_unstemmed | Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. |
| title_short | Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade. |
| title_sort | neuronal cell fate specification by the convergence of different spatiotemporal cues on a common terminal selector cascade |
| url | https://doi.org/10.1371/journal.pbio.1002450 |
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