Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors
Objective Transurethral resection (TUR) of the bladder and intravesical chemotherapy is the standard treatment option for non-muscle-invasive bladder tumors. Inadequate tumor resection results in early recurrence and staging inaccuracies, which all will change the course of the disease. High-qu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2016-03-01
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| Series: | Journal of Urological Surgery |
| Subjects: | |
| Online Access: | http://jurolsurgery.org/article_10383/Influence-Of-The-Presence-Of-Muscularis-Propria-On-Recurrence-And-The-Quality-Of-Transurethral-Resection-In-Low-grade-Stage-Pta-Bladder-Tumors |
| _version_ | 1797914050501279744 |
|---|---|
| author | Hakan Türk Sıtkı Ün Hüseyin Tarhan |
| author_facet | Hakan Türk Sıtkı Ün Hüseyin Tarhan |
| author_sort | Hakan Türk |
| collection | DOAJ |
| description | Objective
Transurethral resection (TUR) of the bladder and intravesical
chemotherapy is the standard treatment option for non-muscle-invasive
bladder tumors. Inadequate tumor resection results in early recurrence
and staging inaccuracies, which all will change the course of the disease.
High-quality TUR treatment is therefore an important factor in the
treatment of non-muscle-invasive bladder tumors. In this study, we
investigated the significance of detecting the presence of muscularis
propria (MP) in pathology specimens of low-grade, stage pTa tumors in
patients who were treated with TUR due to primary bladder tumors, with
regard to recurrence, time to recurrence and progression.
Materials and Methods
Initially, 841 patients who were treated with TUR due to primary bladder
tumors were enrolled in the study. A total of 597 patients were excluded
from the study because they failed to meet the study criteria. Group
1 consisted of patients with MP detected in the pathology specimens;
whereas group 2 consisted of patients whose TUR specimens did not
include MP. The patients were evaluated with regard to gender, tumor
number, presence or absence of MP, and recurrence status.
Results
MP was observed in only 14 (15.2%) of 92 patients with recurrence, but
not in the remaining 78 (84.8%) (p=0.004). Progression occurred in 4 (14.2%) patients of group 1 and 28 (29%) patients of group 2 (p=0.159).
In univariate analysis, tumor multiplicity (p=0.003) and the absence of
MP (p=0.004) were found to have effects on recurrence. In multivariate
analysis, these two parameters were also found to be have effects on
recurrence (p=0.004).
Conclusion
In this study, it was pointed out that MP presence in the pathology
specimens of low-grade stage pTa tumors is an indicator of a high quality
TUR and, a well-done TUR is important for the prevention of recurrence. |
| first_indexed | 2024-04-10T12:20:49Z |
| format | Article |
| id | doaj.art-12d7f15edce9472188a3e7792f237656 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 |
| language | English |
| last_indexed | 2024-04-10T12:20:49Z |
| publishDate | 2016-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-12d7f15edce9472188a3e7792f2376562023-02-15T16:15:27ZengGalenos YayineviJournal of Urological Surgery2148-95802016-03-0131131710.4274/jus.618Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder TumorsHakan Türk0Sıtkı Ün1 Hüseyin Tarhan2Dumlupınar University Faculty of Medicine, Evliya Çelebi Training and Research Hospital, Clinic of Urology, Kütahya, TurkeyKatip Çelebi University Faculty of Medicine, Atatürk Training and Research Hospital, Clinic of Urology, İzmir, TurkeyTepecik Training and Research Hospital, Clinic of Urology, İzmir, TurkeyObjective Transurethral resection (TUR) of the bladder and intravesical chemotherapy is the standard treatment option for non-muscle-invasive bladder tumors. Inadequate tumor resection results in early recurrence and staging inaccuracies, which all will change the course of the disease. High-quality TUR treatment is therefore an important factor in the treatment of non-muscle-invasive bladder tumors. In this study, we investigated the significance of detecting the presence of muscularis propria (MP) in pathology specimens of low-grade, stage pTa tumors in patients who were treated with TUR due to primary bladder tumors, with regard to recurrence, time to recurrence and progression. Materials and Methods Initially, 841 patients who were treated with TUR due to primary bladder tumors were enrolled in the study. A total of 597 patients were excluded from the study because they failed to meet the study criteria. Group 1 consisted of patients with MP detected in the pathology specimens; whereas group 2 consisted of patients whose TUR specimens did not include MP. The patients were evaluated with regard to gender, tumor number, presence or absence of MP, and recurrence status. Results MP was observed in only 14 (15.2%) of 92 patients with recurrence, but not in the remaining 78 (84.8%) (p=0.004). Progression occurred in 4 (14.2%) patients of group 1 and 28 (29%) patients of group 2 (p=0.159). In univariate analysis, tumor multiplicity (p=0.003) and the absence of MP (p=0.004) were found to have effects on recurrence. In multivariate analysis, these two parameters were also found to be have effects on recurrence (p=0.004). Conclusion In this study, it was pointed out that MP presence in the pathology specimens of low-grade stage pTa tumors is an indicator of a high quality TUR and, a well-done TUR is important for the prevention of recurrence.http://jurolsurgery.org/article_10383/Influence-Of-The-Presence-Of-Muscularis-Propria-On-Recurrence-And-The-Quality-Of-Transurethral-Resection-In-Low-grade-Stage-Pta-Bladder-TumorsBladder tumorrecurrencetumor volumemuscularis propria |
| spellingShingle | Hakan Türk Sıtkı Ün Hüseyin Tarhan Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors Journal of Urological Surgery Bladder tumor recurrence tumor volume muscularis propria |
| title | Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors |
| title_full | Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors |
| title_fullStr | Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors |
| title_full_unstemmed | Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors |
| title_short | Influence of the Presence of Muscularis Propria on Recurrence and the Quality of Transurethral Resection in Low-Grade, Stage pTa Bladder Tumors |
| title_sort | influence of the presence of muscularis propria on recurrence and the quality of transurethral resection in low grade stage pta bladder tumors |
| topic | Bladder tumor recurrence tumor volume muscularis propria |
| url | http://jurolsurgery.org/article_10383/Influence-Of-The-Presence-Of-Muscularis-Propria-On-Recurrence-And-The-Quality-Of-Transurethral-Resection-In-Low-grade-Stage-Pta-Bladder-Tumors |
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