A De Novo Designed Trimeric Metalloprotein as a Ni<sub>p</sub> Model of the Acetyl-CoA Synthase

A De Novo Designed Trimeric Metalloprotein as a Ni<sub>p</sub> Model of the Acetyl-CoA Synthase

We present a Ni<sub>p</sub> site model of acetyl coenzyme-A synthase (ACS) within a de novo-designed trimer peptide that self-assembles to produce a homoleptic Ni(Cys)<sub>3</sub> binding motif. Spectroscopic and kinetic studies of ligand binding demonstrate that Ni binding s...

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Bibliographic Details
Main Authors: Dhanashree Selvan, Saumen Chakraborty
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
carbon cycle
acetyl-CoA synthase
de novo proteins
metal-carbonyl
nickel
enzyme models
Online Access:https://www.mdpi.com/1422-0067/24/12/10317

Internet

https://www.mdpi.com/1422-0067/24/12/10317

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