A De Novo Designed Trimeric Metalloprotein as a Ni<sub>p</sub> Model of the Acetyl-CoA Synthase
We present a Ni<sub>p</sub> site model of acetyl coenzyme-A synthase (ACS) within a de novo-designed trimer peptide that self-assembles to produce a homoleptic Ni(Cys)<sub>3</sub> binding motif. Spectroscopic and kinetic studies of ligand binding demonstrate that Ni binding s...
Main Authors: | Dhanashree Selvan, Saumen Chakraborty |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/12/10317 |
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