A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride
Chemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not y...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-09-01
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| Series: | Safety and Health at Work |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2093791115000529 |
| _version_ | 1827886887017119744 |
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| author | Kyung-Taek Rim Soo-Jin Kim |
| author_facet | Kyung-Taek Rim Soo-Jin Kim |
| author_sort | Kyung-Taek Rim |
| collection | DOAJ |
| description | Chemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not yet been conducted, we screened for MN induction by using male ICR mice bone marrow cells. The test results indicated that this chemical is not mutagenic under the test conditions. In this paper, the regulatory test battery and several assay combinations used to determine the genotoxic potential of chemicals in the workplace have been described. Further application of these assays may prove useful in future development strategies of hazard evaluations of industrial chemicals. This study also should help to improve the testing of this chemical by commonly used mutagenicity testing methods and investigations on the underlying mechanisms and could be applicable for workers' health. |
| first_indexed | 2024-03-12T20:10:21Z |
| format | Article |
| id | doaj.art-12d83ae4e29148afa66daf3cf43e29d0 |
| institution | Directory Open Access Journal |
| issn | 2093-7911 |
| language | English |
| last_indexed | 2024-03-12T20:10:21Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Safety and Health at Work |
| spelling | doaj.art-12d83ae4e29148afa66daf3cf43e29d02023-08-02T01:45:31ZengElsevierSafety and Health at Work2093-79112015-09-016318419110.1016/j.shaw.2015.05.005A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl ChlorideKyung-Taek RimSoo-Jin KimChemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not yet been conducted, we screened for MN induction by using male ICR mice bone marrow cells. The test results indicated that this chemical is not mutagenic under the test conditions. In this paper, the regulatory test battery and several assay combinations used to determine the genotoxic potential of chemicals in the workplace have been described. Further application of these assays may prove useful in future development strategies of hazard evaluations of industrial chemicals. This study also should help to improve the testing of this chemical by commonly used mutagenicity testing methods and investigations on the underlying mechanisms and could be applicable for workers' health.http://www.sciencedirect.com/science/article/pii/S2093791115000529allyl chlorideGlobally Harmonized System of Classification and Labeling of Chemicalsmicronucleusmutagenicityoccupational disease |
| spellingShingle | Kyung-Taek Rim Soo-Jin Kim A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride Safety and Health at Work allyl chloride Globally Harmonized System of Classification and Labeling of Chemicals micronucleus mutagenicity occupational disease |
| title | A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride |
| title_full | A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride |
| title_fullStr | A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride |
| title_full_unstemmed | A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride |
| title_short | A Review on Mutagenicity Testing for Hazard Classification of Chemicals at Work: Focusing on in vivo Micronucleus Test for Allyl Chloride |
| title_sort | review on mutagenicity testing for hazard classification of chemicals at work focusing on in vivo micronucleus test for allyl chloride |
| topic | allyl chloride Globally Harmonized System of Classification and Labeling of Chemicals micronucleus mutagenicity occupational disease |
| url | http://www.sciencedirect.com/science/article/pii/S2093791115000529 |
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