Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro
Naringin, a flavanone glycoside, and naringenin, the aglycone of naringin, are commonly found in the pericarp of citrus fruits and have also been considered as potential bioactive flavanones. In the present study, treatment with naringenin showed an inhibitory effect on SIV formation in zebrafish em...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618304341 |
| _version_ | 1818728251148730368 |
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| author | Linmin Chen Binrui Yang Benqin Tang Guiyi Gong Hiotong Kam Cheng Gao Yan Chen Ruibing Wang Simon Ming Yuen Lee |
| author_facet | Linmin Chen Binrui Yang Benqin Tang Guiyi Gong Hiotong Kam Cheng Gao Yan Chen Ruibing Wang Simon Ming Yuen Lee |
| author_sort | Linmin Chen |
| collection | DOAJ |
| description | Naringin, a flavanone glycoside, and naringenin, the aglycone of naringin, are commonly found in the pericarp of citrus fruits and have also been considered as potential bioactive flavanones. In the present study, treatment with naringenin showed an inhibitory effect on SIV formation in zebrafish embryos, which demonstrates its potential anti-angiogenic activity. In a chemically-induced blood vessel loss model in zebrafish, we found that naringin exhibited remarkably pro-angiogenesis activity on the restoration of blood vessel loss, and significantly reversed VRI-induced down-regulation of flt1 mRNA expression. In an in vitro study of cultured human umbilical vein endothelial cells (HUVEC), our results showed that naringin specifically promoted HUVEC migration but not proliferation. Taken together, these results suggest that naringin and naringenin have differential angiogenesis activities where naringin, as a novel angiogenic agent, has the potential to be developed as a therapeutic agent for diseases associated with insufficient angiogenesis, such as ischemia heart disease. |
| first_indexed | 2024-12-17T22:27:01Z |
| format | Article |
| id | doaj.art-12d8eaea413947c7b5c0f9f9732430ce |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T22:27:01Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-12d8eaea413947c7b5c0f9f9732430ce2022-12-21T21:30:19ZengElsevierJournal of Functional Foods1756-46462018-10-0149369377Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitroLinmin Chen0Binrui Yang1Benqin Tang2Guiyi Gong3Hiotong Kam4Cheng Gao5Yan Chen6Ruibing Wang7Simon Ming Yuen Lee8State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China; Department of Medical Science, Shunde Polytechnic, Foshan, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China; Corresponding author at: 7F, N22 Building, University of Macau, Avenida da Universidade, Taipa, Macau, China.Naringin, a flavanone glycoside, and naringenin, the aglycone of naringin, are commonly found in the pericarp of citrus fruits and have also been considered as potential bioactive flavanones. In the present study, treatment with naringenin showed an inhibitory effect on SIV formation in zebrafish embryos, which demonstrates its potential anti-angiogenic activity. In a chemically-induced blood vessel loss model in zebrafish, we found that naringin exhibited remarkably pro-angiogenesis activity on the restoration of blood vessel loss, and significantly reversed VRI-induced down-regulation of flt1 mRNA expression. In an in vitro study of cultured human umbilical vein endothelial cells (HUVEC), our results showed that naringin specifically promoted HUVEC migration but not proliferation. Taken together, these results suggest that naringin and naringenin have differential angiogenesis activities where naringin, as a novel angiogenic agent, has the potential to be developed as a therapeutic agent for diseases associated with insufficient angiogenesis, such as ischemia heart disease.http://www.sciencedirect.com/science/article/pii/S1756464618304341AngiogenesisNaringinZebrafishHUVEC |
| spellingShingle | Linmin Chen Binrui Yang Benqin Tang Guiyi Gong Hiotong Kam Cheng Gao Yan Chen Ruibing Wang Simon Ming Yuen Lee Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro Journal of Functional Foods Angiogenesis Naringin Zebrafish HUVEC |
| title | Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| title_full | Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| title_fullStr | Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| title_full_unstemmed | Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| title_short | Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| title_sort | differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro |
| topic | Angiogenesis Naringin Zebrafish HUVEC |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618304341 |
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