Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration
Abstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the impl...
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| Format: | Artikel |
| Sprache: | English |
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Wiley
2023-10-01
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| Schriftenreihe: | Advanced Science |
| Schlagworte: | |
| Online Zugang: | https://doi.org/10.1002/advs.202303958 |
| _version_ | 1826966250945773568 |
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| author | Yuan Zhang Zhuo Cheng Zaiyang Liu Xinkun Shen Chunyuan Cai Menghuan Li Zhong Luo |
| author_facet | Yuan Zhang Zhuo Cheng Zaiyang Liu Xinkun Shen Chunyuan Cai Menghuan Li Zhong Luo |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Abstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the implants, leading to severe adverse complications including implant loosening, detachment, and secondary bone damage. Consequently, new Ti implant engineering strategies are urgently needed to improve their osseointegration after implantation. Remarkably, metalorganic frameworks (MOFs) are a class of novel synthetic material consisting of coordinated metal species and organic ligands, which have demonstrated a plethora of favorable properties for modulating the interfacial properties of Ti implants. This review comprehensively summarizes the recent progress in the development of MOF‐coated Ti implants and highlights their potential utility for modulating the bio‐implant interface to improve implant osseointegration, of which the discussions are outlined according to their physical traits, chemical composition, and drug delivery capacity. A perspective is also provided in this review regarding the current limitations and future opportunities of MOF‐coated Ti implants for orthopedic applications. The insights in this review may facilitate the rational design of more advanced Ti implants with enhanced therapeutic performance and safety. |
| first_indexed | 2024-03-11T17:50:39Z |
| format | Article |
| id | doaj.art-12d9762021d94f7584fe0ceac3fb7ecd |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2025-02-18T03:31:58Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-12d9762021d94f7584fe0ceac3fb7ecd2024-11-22T13:11:48ZengWileyAdvanced Science2198-38442023-10-011029n/an/a10.1002/advs.202303958Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant OsseointegrationYuan Zhang0Zhuo Cheng1Zaiyang Liu2Xinkun Shen3Chunyuan Cai4Menghuan Li5Zhong Luo6Joint Disease & Sport Medicine Centre Department of Orthopaedics Xinqiao Hospital Army Medical University Chongqing 400038 ChinaSchool of Life Science Chongqing University Chongqing 400044 ChinaJoint Disease & Sport Medicine Centre Department of Orthopaedics Xinqiao Hospital Army Medical University Chongqing 400038 ChinaDepartment of Orthopaedics Ruian People's Hospital The Third Affiliated Hospital of Wenzhou Medical University Wenzhou 325016 ChinaDepartment of Orthopaedics Ruian People's Hospital The Third Affiliated Hospital of Wenzhou Medical University Wenzhou 325016 ChinaSchool of Life Science Chongqing University Chongqing 400044 ChinaSchool of Life Science Chongqing University Chongqing 400044 ChinaAbstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the implants, leading to severe adverse complications including implant loosening, detachment, and secondary bone damage. Consequently, new Ti implant engineering strategies are urgently needed to improve their osseointegration after implantation. Remarkably, metalorganic frameworks (MOFs) are a class of novel synthetic material consisting of coordinated metal species and organic ligands, which have demonstrated a plethora of favorable properties for modulating the interfacial properties of Ti implants. This review comprehensively summarizes the recent progress in the development of MOF‐coated Ti implants and highlights their potential utility for modulating the bio‐implant interface to improve implant osseointegration, of which the discussions are outlined according to their physical traits, chemical composition, and drug delivery capacity. A perspective is also provided in this review regarding the current limitations and future opportunities of MOF‐coated Ti implants for orthopedic applications. The insights in this review may facilitate the rational design of more advanced Ti implants with enhanced therapeutic performance and safety.https://doi.org/10.1002/advs.202303958bone‐implant interfacemetal‐organic frameworksosseointegrationtitanium implants |
| spellingShingle | Yuan Zhang Zhuo Cheng Zaiyang Liu Xinkun Shen Chunyuan Cai Menghuan Li Zhong Luo Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration Advanced Science bone‐implant interface metal‐organic frameworks osseointegration titanium implants |
| title | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration |
| title_full | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration |
| title_fullStr | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration |
| title_full_unstemmed | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration |
| title_short | Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration |
| title_sort | functionally tailored metal organic framework coatings for mediating ti implant osseointegration |
| topic | bone‐implant interface metal‐organic frameworks osseointegration titanium implants |
| url | https://doi.org/10.1002/advs.202303958 |
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