Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms. We also describe how th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-09-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00183/full |
| _version_ | 1831656420607524864 |
|---|---|
| author | Akshay Bareja David E. Lee James P. White James P. White James P. White |
| author_facet | Akshay Bareja David E. Lee James P. White James P. White James P. White |
| author_sort | Akshay Bareja |
| collection | DOAJ |
| description | Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms. We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis. Finally, we consider various approaches of therapeutically modulating these longevity pathways, highlighting exercise as a potent geroprotector. |
| first_indexed | 2024-12-19T17:07:49Z |
| format | Article |
| id | doaj.art-12da4e8aab0a4b238d07084513342ee6 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T17:07:49Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-12da4e8aab0a4b238d07084513342ee62022-12-21T20:13:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-09-01710.3389/fcell.2019.00183470191Maximizing Longevity and Healthspan: Multiple Approaches All Converging on AutophagyAkshay Bareja0David E. Lee1James P. White2James P. White3James P. White4Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United StatesDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United StatesDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United StatesDivision of Hematology, Department of Medicine, Duke University School of Medicine, Durham, NC, United StatesDuke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, United StatesOur understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms. We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis. Finally, we consider various approaches of therapeutically modulating these longevity pathways, highlighting exercise as a potent geroprotector.https://www.frontiersin.org/article/10.3389/fcell.2019.00183/fullautophagylongevityagingexercisehealthspan |
| spellingShingle | Akshay Bareja David E. Lee James P. White James P. White James P. White Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy Frontiers in Cell and Developmental Biology autophagy longevity aging exercise healthspan |
| title | Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy |
| title_full | Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy |
| title_fullStr | Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy |
| title_full_unstemmed | Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy |
| title_short | Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy |
| title_sort | maximizing longevity and healthspan multiple approaches all converging on autophagy |
| topic | autophagy longevity aging exercise healthspan |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00183/full |
| work_keys_str_mv | AT akshaybareja maximizinglongevityandhealthspanmultipleapproachesallconvergingonautophagy AT davidelee maximizinglongevityandhealthspanmultipleapproachesallconvergingonautophagy AT jamespwhite maximizinglongevityandhealthspanmultipleapproachesallconvergingonautophagy AT jamespwhite maximizinglongevityandhealthspanmultipleapproachesallconvergingonautophagy AT jamespwhite maximizinglongevityandhealthspanmultipleapproachesallconvergingonautophagy |