Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database
<b>Background and Aim:</b> Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with other somatic disorders. We studied the prevalence and predictors of fibromyalgia and chronic fatigue syndrome (CFS) in IBS patients. <b>Methods:</b> We used th...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2594 |
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| author | Zahid Ijaz Tarar Umer Farooq Ahmad Nawaz Mustafa Gandhi Yezaz A. Ghouri Asmeen Bhatt Brooks D. Cash |
| author_facet | Zahid Ijaz Tarar Umer Farooq Ahmad Nawaz Mustafa Gandhi Yezaz A. Ghouri Asmeen Bhatt Brooks D. Cash |
| author_sort | Zahid Ijaz Tarar |
| collection | DOAJ |
| description | <b>Background and Aim:</b> Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with other somatic disorders. We studied the prevalence and predictors of fibromyalgia and chronic fatigue syndrome (CFS) in IBS patients. <b>Methods:</b> We used the National Inpatient Sample and included hospitalization of individuals with IBS, using ICD-10 codes, from 2016–2019. The prevalence and predictors of fibromyalgia and CFS in IBS patients were studied. Univariate and multivariate patient- and hospital-level regression models were used to calculate the adjusted odds of fibromyalgia and CFS in the IBS patient population. <b>Results:</b> Of 1,256,325 patients with an ICD-10 code of IBS included in the study, 10.73% (134,890) also had ICD-10 codes for fibromyalgia and 0.42% (5220) for CFS. The prevalence of fibromyalgia and CFS was significantly higher in IBS patients (adjusted odds ratio (AOR) 5.33, 95% confidence interval (CI) 5.24–5.41, <i>p</i> < 0.001, and AOR 5.40, 95% CI 5.04–5.78, <i>p</i> < 0.001, respectively) compared to the general adult population without IBS. IBS-diarrhea, IBS-constipation, and IBS-mixed types were independently associated with increased odds of fibromyalgia and CFS. Increasing age (AOR 1.02, 95% CI 1.01–1.04, <i>p</i> 0.003; AOR 1.02, 95% CI 1.01–1.03, <i>p</i> 0.001), female gender (AOR 11.2, 95% CI 11.1–11.4, <i>p</i> < 0.001; AOR 1.86, 95% CI 1.78–1.93, <i>p</i> < 0.001) and white race (AOR 2.04, 95% CI 1.95–2.12, <i>p</i> < 0.001; AOR 1.69, 95% CI 1.34–2.13, <i>p</i> < 0.001) were independent predictors of increased odds of fibromyalgia and CFS, respectively. <b>Conclusions:</b> It appears that IBS is associated with an increased prevalence of somatic disorders such as fibromyalgia and CFS. |
| first_indexed | 2024-03-10T21:25:09Z |
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| language | English |
| last_indexed | 2024-03-10T21:25:09Z |
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| spelling | doaj.art-12dafa765355401cb2e9b2cffa57acbc2023-11-19T15:44:15ZengMDPI AGBiomedicines2227-90592023-09-011110259410.3390/biomedicines11102594Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample DatabaseZahid Ijaz Tarar0Umer Farooq1Ahmad Nawaz2Mustafa Gandhi3Yezaz A. Ghouri4Asmeen Bhatt5Brooks D. Cash6Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, USADivision of Gastroenterology and Hepatology, Saint Louis University, St. Louis, MO 63103, USADivision of Gastroenterology and Hepatology, Suny Upstate Medical University, Syracuse, NY 13210, USADepartment of Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USADivision of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, USACenter for Interventional Gastroenterology at UTHealth (iGUT), Division of Elective Surgery, Department of Surgery, University of Texas Health Medical School, Houston, TX 77030, USADivision of Gastroenterology & Hepatology, University of Texas Health-McGovern Medical School and UT Health Science Center at Houston, St. Houston, TX 77054, USA<b>Background and Aim:</b> Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with other somatic disorders. We studied the prevalence and predictors of fibromyalgia and chronic fatigue syndrome (CFS) in IBS patients. <b>Methods:</b> We used the National Inpatient Sample and included hospitalization of individuals with IBS, using ICD-10 codes, from 2016–2019. The prevalence and predictors of fibromyalgia and CFS in IBS patients were studied. Univariate and multivariate patient- and hospital-level regression models were used to calculate the adjusted odds of fibromyalgia and CFS in the IBS patient population. <b>Results:</b> Of 1,256,325 patients with an ICD-10 code of IBS included in the study, 10.73% (134,890) also had ICD-10 codes for fibromyalgia and 0.42% (5220) for CFS. The prevalence of fibromyalgia and CFS was significantly higher in IBS patients (adjusted odds ratio (AOR) 5.33, 95% confidence interval (CI) 5.24–5.41, <i>p</i> < 0.001, and AOR 5.40, 95% CI 5.04–5.78, <i>p</i> < 0.001, respectively) compared to the general adult population without IBS. IBS-diarrhea, IBS-constipation, and IBS-mixed types were independently associated with increased odds of fibromyalgia and CFS. Increasing age (AOR 1.02, 95% CI 1.01–1.04, <i>p</i> 0.003; AOR 1.02, 95% CI 1.01–1.03, <i>p</i> 0.001), female gender (AOR 11.2, 95% CI 11.1–11.4, <i>p</i> < 0.001; AOR 1.86, 95% CI 1.78–1.93, <i>p</i> < 0.001) and white race (AOR 2.04, 95% CI 1.95–2.12, <i>p</i> < 0.001; AOR 1.69, 95% CI 1.34–2.13, <i>p</i> < 0.001) were independent predictors of increased odds of fibromyalgia and CFS, respectively. <b>Conclusions:</b> It appears that IBS is associated with an increased prevalence of somatic disorders such as fibromyalgia and CFS.https://www.mdpi.com/2227-9059/11/10/2594fibromyalgiachronic fatigue syndromeIBSirritable bowel syndrome |
| spellingShingle | Zahid Ijaz Tarar Umer Farooq Ahmad Nawaz Mustafa Gandhi Yezaz A. Ghouri Asmeen Bhatt Brooks D. Cash Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database Biomedicines fibromyalgia chronic fatigue syndrome IBS irritable bowel syndrome |
| title | Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database |
| title_full | Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database |
| title_fullStr | Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database |
| title_full_unstemmed | Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database |
| title_short | Prevalence of Fibromyalgia and Chronic Fatigue Syndrome among Individuals with Irritable Bowel Syndrome: An Analysis of United States National Inpatient Sample Database |
| title_sort | prevalence of fibromyalgia and chronic fatigue syndrome among individuals with irritable bowel syndrome an analysis of united states national inpatient sample database |
| topic | fibromyalgia chronic fatigue syndrome IBS irritable bowel syndrome |
| url | https://www.mdpi.com/2227-9059/11/10/2594 |
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