Molecular modeling of fentanyl analogs
Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relation...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2004-11-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.shd.org.yu/HtDocs/SHD/Vol69/No11/V69-No11-02.pdf |
| _version_ | 1828762521393168384 |
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| author | LJILJANA DOSEN-MICOVIC |
| author_facet | LJILJANA DOSEN-MICOVIC |
| author_sort | LJILJANA DOSEN-MICOVIC |
| collection | DOAJ |
| description | Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper. |
| first_indexed | 2024-12-11T01:46:46Z |
| format | Article |
| id | doaj.art-12dd2a9f1b2c41a18bbcf0de1b20ef9a |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-11T01:46:46Z |
| publishDate | 2004-11-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-12dd2a9f1b2c41a18bbcf0de1b20ef9a2022-12-22T01:24:53ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392004-11-016911843854Molecular modeling of fentanyl analogsLJILJANA DOSEN-MICOVICFentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.http://www.shd.org.yu/HtDocs/SHD/Vol69/No11/V69-No11-02.pdffentanyl analogsmolecular modelingm-receptorligand-receptor interactions |
| spellingShingle | LJILJANA DOSEN-MICOVIC Molecular modeling of fentanyl analogs Journal of the Serbian Chemical Society fentanyl analogs molecular modeling m-receptor ligand-receptor interactions |
| title | Molecular modeling of fentanyl analogs |
| title_full | Molecular modeling of fentanyl analogs |
| title_fullStr | Molecular modeling of fentanyl analogs |
| title_full_unstemmed | Molecular modeling of fentanyl analogs |
| title_short | Molecular modeling of fentanyl analogs |
| title_sort | molecular modeling of fentanyl analogs |
| topic | fentanyl analogs molecular modeling m-receptor ligand-receptor interactions |
| url | http://www.shd.org.yu/HtDocs/SHD/Vol69/No11/V69-No11-02.pdf |
| work_keys_str_mv | AT ljiljanadosenmicovic molecularmodelingoffentanylanalogs |