A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum
Abstract Background Omentectomy is an important procedure in surgery for epithelial ovarian cancer, but the scope of omentectomy is not recommended in the guidelines. This study was performed to evaluate the benefits and risks of infragastric omentectomy in patients with epithelial ovarian cancer. M...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-024-01401-8 |
| _version_ | 1797199240383954944 |
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| author | Xuhui Dong Lei Yuan Ruoyao Zou Liangqing Yao |
| author_facet | Xuhui Dong Lei Yuan Ruoyao Zou Liangqing Yao |
| author_sort | Xuhui Dong |
| collection | DOAJ |
| description | Abstract Background Omentectomy is an important procedure in surgery for epithelial ovarian cancer, but the scope of omentectomy is not recommended in the guidelines. This study was performed to evaluate the benefits and risks of infragastric omentectomy in patients with epithelial ovarian cancer. Methods This trial is a single center prospective study. Primary epithelial ovarian cancer patients with normal-appearing omentum were randomly assigned to either the control or experimental group and underwent infracolic or infragastric omentectomy, respectively. The primary endpoint was progression-free survival. This trial is registered on Chinese clinical trial registry site (ChiCTR1800018771). Results A total of 106 patients meeting the inclusion criteria for ovarian cancer were included during the study period. Of these, 53 patients underwent infracolic omentectomy, whereas 53 patients received infragastric omentectomy. Multivariate analysis revealed that infragastric omentectomy could improve the detection rate of omental metastases (OR: 6.519, P = 0.005). Infragastric omentectomy improved progression-free survival significantly for those cases with higher than stage IIB disease (HR: 0.456, P = 0.041). Based on the short-term results, infragastric omentectomy did not cause more perioperative complications. Conclusions Compared with infracolic omentectomy, infragrastric omentectomy may be a more appropriate surgical procedure for stage IIB-IIIC epithelial ovarian cancer patients with normal-appearing omentum. |
| first_indexed | 2024-04-24T07:12:37Z |
| format | Article |
| id | doaj.art-12def5dfd0234c4986a57b06e05a9644 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-24T07:12:37Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-12def5dfd0234c4986a57b06e05a96442024-04-21T11:27:12ZengBMCJournal of Ovarian Research1757-22152024-04-0117111110.1186/s13048-024-01401-8A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentumXuhui Dong0Lei Yuan1Ruoyao Zou2Liangqing Yao3Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant HospitalDepartment of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical CenterAbstract Background Omentectomy is an important procedure in surgery for epithelial ovarian cancer, but the scope of omentectomy is not recommended in the guidelines. This study was performed to evaluate the benefits and risks of infragastric omentectomy in patients with epithelial ovarian cancer. Methods This trial is a single center prospective study. Primary epithelial ovarian cancer patients with normal-appearing omentum were randomly assigned to either the control or experimental group and underwent infracolic or infragastric omentectomy, respectively. The primary endpoint was progression-free survival. This trial is registered on Chinese clinical trial registry site (ChiCTR1800018771). Results A total of 106 patients meeting the inclusion criteria for ovarian cancer were included during the study period. Of these, 53 patients underwent infracolic omentectomy, whereas 53 patients received infragastric omentectomy. Multivariate analysis revealed that infragastric omentectomy could improve the detection rate of omental metastases (OR: 6.519, P = 0.005). Infragastric omentectomy improved progression-free survival significantly for those cases with higher than stage IIB disease (HR: 0.456, P = 0.041). Based on the short-term results, infragastric omentectomy did not cause more perioperative complications. Conclusions Compared with infracolic omentectomy, infragrastric omentectomy may be a more appropriate surgical procedure for stage IIB-IIIC epithelial ovarian cancer patients with normal-appearing omentum.https://doi.org/10.1186/s13048-024-01401-8Epithelial ovarian cancerInfracolic omentectomyInfragrastric omentectomyShort-term outcomesOmental metastases |
| spellingShingle | Xuhui Dong Lei Yuan Ruoyao Zou Liangqing Yao A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum Journal of Ovarian Research Epithelial ovarian cancer Infracolic omentectomy Infragrastric omentectomy Short-term outcomes Omental metastases |
| title | A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum |
| title_full | A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum |
| title_fullStr | A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum |
| title_full_unstemmed | A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum |
| title_short | A randomized controlled trial to compare short-term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal-appearing omentum |
| title_sort | randomized controlled trial to compare short term outcomes following infragastric and infracolic omentectomy at the time of primary debulking surgery for epithelial ovarian cancer with normal appearing omentum |
| topic | Epithelial ovarian cancer Infracolic omentectomy Infragrastric omentectomy Short-term outcomes Omental metastases |
| url | https://doi.org/10.1186/s13048-024-01401-8 |
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