Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor
In membranous nephropathy, the presence of antibodies against M-type phospholipase A2 receptor is considered highly specific for idiopathic forms. However, no specific association to a particular clinical profile has been found for such antibodies. Objective: To assess potential differences in initi...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Nefrología (English Edition) |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2013251415000838 |
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| author | Elías Jatem Escalante Alfons Segarra Medrano Clara Carnicer Cáceres M. Adoración Martín-Gómez María Teresa Salcedo Allende Helena Ostos Roldan Irene Agraz Pamplona |
| author_facet | Elías Jatem Escalante Alfons Segarra Medrano Clara Carnicer Cáceres M. Adoración Martín-Gómez María Teresa Salcedo Allende Helena Ostos Roldan Irene Agraz Pamplona |
| author_sort | Elías Jatem Escalante |
| collection | DOAJ |
| description | In membranous nephropathy, the presence of antibodies against M-type phospholipase A2 receptor is considered highly specific for idiopathic forms. However, no specific association to a particular clinical profile has been found for such antibodies.
Objective: To assess potential differences in initial clinical profile, course and prognosis of idiopathic membranous nephropathy depending on the presence of anti-PLA2R antibodies.
Methods: Eighty-five patients with idiopathic membranous nephropathy were included (55 anti-PLA2R-positive and 30 anti-PLA2R-negative). Clinical, biochemical and pathological variables were recorded at the time of diagnosis. Frequency of spontaneous remission, incidence of response to first-line therapy, frequency and number of recurrences, survival of renal function free from renal replacement therapy, survival of renal function free from chronic renal insufficiency and frequency of occurrence of malignant, infectious or autoimmune diseases during follow-up were recorded.
Results: At the time of diagnosis, anti-PLA2R-negative patients were significantly older and had a higher frequency of spontaneous remission. No differences were noted in the response to first-line treatment, frequency and number of recurrences, survival of renal function free from renal replacement therapy, or survival of renal function free from chronic renal insufficiency.
Conclusions: Anti-PLA2R-negative patients with idiopathic membranous nephropathy were older and experienced spontaneous remission more often than anti-PLA2R-positive patients. No differences in terms of treatment response, recurrences, and final prognosis were observed between both groups of patients. |
| first_indexed | 2024-12-13T07:07:41Z |
| format | Article |
| id | doaj.art-12df8bdb7bbb4407a481f674ade27c1d |
| institution | Directory Open Access Journal |
| issn | 2013-2514 |
| language | English |
| last_indexed | 2024-12-13T07:07:41Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nefrología (English Edition) |
| spelling | doaj.art-12df8bdb7bbb4407a481f674ade27c1d2022-12-21T23:55:45ZengElsevierNefrología (English Edition)2013-25142015-09-0135547948610.1016/j.nefroe.2015.10.006Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptorElías Jatem Escalante0Alfons Segarra Medrano1Clara Carnicer Cáceres2M. Adoración Martín-Gómez3María Teresa Salcedo Allende4Helena Ostos Roldan5Irene Agraz Pamplona6Servicio de Nefrología, Hospital Universitari Vall d́Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainServicio de Nefrología, Hospital Universitari Vall d́Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainServicio de Bioquímica, Hospital Universitari Vall d́Hebron, Barcelona, SpainUnidad de Nefrología, Hospital de Poniente, El Ejido, Almería, SpainServicio de Patología, Hospital Universitari Vall d́Hebron, Barcelona, SpainServicio de Nefrología, Hospital Universitari Vall d́Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainServicio de Nefrología, Hospital Universitari Vall d́Hebron, Universidad Autónoma de Barcelona, Barcelona, SpainIn membranous nephropathy, the presence of antibodies against M-type phospholipase A2 receptor is considered highly specific for idiopathic forms. However, no specific association to a particular clinical profile has been found for such antibodies. Objective: To assess potential differences in initial clinical profile, course and prognosis of idiopathic membranous nephropathy depending on the presence of anti-PLA2R antibodies. Methods: Eighty-five patients with idiopathic membranous nephropathy were included (55 anti-PLA2R-positive and 30 anti-PLA2R-negative). Clinical, biochemical and pathological variables were recorded at the time of diagnosis. Frequency of spontaneous remission, incidence of response to first-line therapy, frequency and number of recurrences, survival of renal function free from renal replacement therapy, survival of renal function free from chronic renal insufficiency and frequency of occurrence of malignant, infectious or autoimmune diseases during follow-up were recorded. Results: At the time of diagnosis, anti-PLA2R-negative patients were significantly older and had a higher frequency of spontaneous remission. No differences were noted in the response to first-line treatment, frequency and number of recurrences, survival of renal function free from renal replacement therapy, or survival of renal function free from chronic renal insufficiency. Conclusions: Anti-PLA2R-negative patients with idiopathic membranous nephropathy were older and experienced spontaneous remission more often than anti-PLA2R-positive patients. No differences in terms of treatment response, recurrences, and final prognosis were observed between both groups of patients.http://www.sciencedirect.com/science/article/pii/S2013251415000838Idiopathic membranous nephropathyAnti-PLA2R antibodiesNephrotic syndromePrognosis |
| spellingShingle | Elías Jatem Escalante Alfons Segarra Medrano Clara Carnicer Cáceres M. Adoración Martín-Gómez María Teresa Salcedo Allende Helena Ostos Roldan Irene Agraz Pamplona Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor Nefrología (English Edition) Idiopathic membranous nephropathy Anti-PLA2R antibodies Nephrotic syndrome Prognosis |
| title | Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor |
| title_full | Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor |
| title_fullStr | Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor |
| title_full_unstemmed | Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor |
| title_short | Clinical features, course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against M-type phospholipase A2 receptor |
| title_sort | clinical features course and prognosis of idiopathic membranous nephropathy depending on the presence of antibodies against m type phospholipase a2 receptor |
| topic | Idiopathic membranous nephropathy Anti-PLA2R antibodies Nephrotic syndrome Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2013251415000838 |
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