Peripheral injury of pelvic visceral sensory nerves alters GFRa (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord

Peripheral injury of pelvic visceral sensory nerves alters GFRa (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord

GDNF (glial cell line-derived neurotrophic factor), neurturin and artemin use their co-receptors (GFRα1, GFRα2 and GFRα3, respectively) and the tyrosine kinase Ret for downstream signalling. In rodent dorsal root ganglia (DRG) most of the unmyelinated and some myelinated sensory afferents express at...

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Bibliographic Details
Main Authors: Shelley Lynne Forrest, Sophie Clementine Payne, Janet R Keast, Peregrine B Osborne
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Neuroanatomy
Subjects:
Autonomic Pathways
Parasympathetic Nervous System
Pelvic Pain
Visceral Afferents
Nerve injury
Dorsal horn
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00043/full

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