Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Methods A multicentre, prospective observational study w...

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Bibliographic Details
Main Authors: James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Microbiome
Subjects:
Colorectal cancer
Gut microbiota
Metabolome
Metataxonomics
Online Access:https://doi.org/10.1186/s40168-023-01518-w

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