Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

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Bibliographic Details
Main Authors: Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Physiology
Subjects:
insulin/IGF-1 receptors
FoxO transcription factors
muscle transcription
diabetes
RNA sequencing
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.779121/full

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