Impact of Growth Hormone on Microglial and Astrocytic Function
The role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of cognition, and regulation of metabolism. As GH induces insulin-like growth factor-1 (IGF-1) expression in many tissues, differentiating the spe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2024-02-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302032 |
| _version_ | 1827572788807860224 |
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| author | Mariana R. Tavares Frederick Wasinski Martin Metzger Jose Donato Jr. |
| author_facet | Mariana R. Tavares Frederick Wasinski Martin Metzger Jose Donato Jr. |
| author_sort | Mariana R. Tavares |
| collection | DOAJ |
| description | The role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of cognition, and regulation of metabolism. As GH induces insulin-like growth factor-1 (IGF-1) expression in many tissues, differentiating the specific functions of GH and IGF-1 in the organism is a significant challenge. The actions of GH and IGF-1 in neurons have been more extensively studied than their functions in nonneuronal cells (e.g., microglial cells). Glial cells are fundamentally important to CNS function. Microglia, astrocytes, oligodendrocytes, and tanycytes are essential to the survival, differentiation, and proliferation of neurons. As the interaction of the GH/IGF-1 axis with glial cells merits further exploration, our objective for this review was to summarize and discuss the available literature regarding the genuine effects of GH on glial cells, seeking to differentiate them from the role played by IGF-1 action whenever possible. |
| first_indexed | 2024-03-07T19:37:18Z |
| format | Article |
| id | doaj.art-12e3309097844cc2b2768391d9ee8cab |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-07T19:37:18Z |
| publishDate | 2024-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-12e3309097844cc2b2768391d9ee8cab2024-02-29T08:00:15ZengIMR PressJournal of Integrative Neuroscience0219-63522024-02-012323210.31083/j.jin2302032S0219-6352(23)00603-4Impact of Growth Hormone on Microglial and Astrocytic FunctionMariana R. Tavares0Frederick Wasinski1Martin Metzger2Jose Donato Jr.3Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508-000, BrazilDepartment of Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Sao Paulo, SP 04039-032, BrazilDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508-000, BrazilDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508-000, BrazilThe role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of cognition, and regulation of metabolism. As GH induces insulin-like growth factor-1 (IGF-1) expression in many tissues, differentiating the specific functions of GH and IGF-1 in the organism is a significant challenge. The actions of GH and IGF-1 in neurons have been more extensively studied than their functions in nonneuronal cells (e.g., microglial cells). Glial cells are fundamentally important to CNS function. Microglia, astrocytes, oligodendrocytes, and tanycytes are essential to the survival, differentiation, and proliferation of neurons. As the interaction of the GH/IGF-1 axis with glial cells merits further exploration, our objective for this review was to summarize and discuss the available literature regarding the genuine effects of GH on glial cells, seeking to differentiate them from the role played by IGF-1 action whenever possible.https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302032microgliaastrocyteoligodendrocytetanycyteghigf-1neuroinflammation |
| spellingShingle | Mariana R. Tavares Frederick Wasinski Martin Metzger Jose Donato Jr. Impact of Growth Hormone on Microglial and Astrocytic Function Journal of Integrative Neuroscience microglia astrocyte oligodendrocyte tanycyte gh igf-1 neuroinflammation |
| title | Impact of Growth Hormone on Microglial and Astrocytic Function |
| title_full | Impact of Growth Hormone on Microglial and Astrocytic Function |
| title_fullStr | Impact of Growth Hormone on Microglial and Astrocytic Function |
| title_full_unstemmed | Impact of Growth Hormone on Microglial and Astrocytic Function |
| title_short | Impact of Growth Hormone on Microglial and Astrocytic Function |
| title_sort | impact of growth hormone on microglial and astrocytic function |
| topic | microglia astrocyte oligodendrocyte tanycyte gh igf-1 neuroinflammation |
| url | https://www.imrpress.com/journal/JIN/23/2/10.31083/j.jin2302032 |
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