2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment
For the first time, zinc oxide (ZnO) nanoparticles (NPs) are synthesized by the green combustion method using apple peel extract as a reducing agent. Further, ZnO-Deoxy-d-Glucose (2DG) nanohybrids were synthesized by the sputtering method. These synthesized biomolecule-coated NPs and nanohybrids are...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217923000564 |
| _version_ | 1797737262816952320 |
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| author | Y.S. Vidya H.C. Manjunatha S. Manjunatha K.N. Sridhar L. Seenappa R. Munirathnam |
| author_facet | Y.S. Vidya H.C. Manjunatha S. Manjunatha K.N. Sridhar L. Seenappa R. Munirathnam |
| author_sort | Y.S. Vidya |
| collection | DOAJ |
| description | For the first time, zinc oxide (ZnO) nanoparticles (NPs) are synthesized by the green combustion method using apple peel extract as a reducing agent. Further, ZnO-Deoxy-d-Glucose (2DG) nanohybrids were synthesized by the sputtering method. These synthesized biomolecule-coated NPs and nanohybrids are characterized with different techniques. The Bragg reflections confirm the hexagonal Wurtzite structure for ZnO. A decrease in crystallite size and an increase in energy band gap were observed for ZnO and ZnO-2DG. The tuning of the band gap plays a vital role in cytotoxicity, arbitrated by intracellular reactive oxygen species. The cytotoxic properties, such as the percentage of inhibition and the percentage of the proliferation of ZnO and ZnO-2DG nanohybrid, are examined against the Kidney cancer Vero cell line and also compared with the standard drugs Levofloxacin and Doxorubicin. Compared to ZnO, ZnO-2DG shows excellent cytotoxic properties, even better than the standard drug against the Vero cell line. Thus, the present ZnO-2DG nanohybrid might be used as a nanodrug and go on to replace Levofloxacin and Doxorubicin as standard drugs in kidney cancer cell therapy. |
| first_indexed | 2024-03-12T13:27:07Z |
| format | Article |
| id | doaj.art-12e3349054b54ed9b29d52d1e651902b |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-03-12T13:27:07Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-12e3349054b54ed9b29d52d1e651902b2023-08-25T04:24:32ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792023-09-01831005872-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatmentY.S. Vidya0H.C. Manjunatha1S. Manjunatha2K.N. Sridhar3L. Seenappa4R. Munirathnam5Department of Physics, Lal Bahadur Shastri Government First Grade College, RT Nagar, Bangalore, 560032, Karnataka, India; Corresponding author.Department of Physics, Government College for Women, Kolar, 563101, Karnataka, India; Corresponding author.Department of Chemistry, B.M.S College of Engineering, Bengaluru, 560019, Karnataka, IndiaDepartment of Physics, Government First Grade College, Kolar, 563101, Karnataka, IndiaDepartment of Physics, Government College for Women, Kolar, 563101, Karnataka, IndiaDepartment of Physics, Government College for Women, Kolar, 563101, Karnataka, IndiaFor the first time, zinc oxide (ZnO) nanoparticles (NPs) are synthesized by the green combustion method using apple peel extract as a reducing agent. Further, ZnO-Deoxy-d-Glucose (2DG) nanohybrids were synthesized by the sputtering method. These synthesized biomolecule-coated NPs and nanohybrids are characterized with different techniques. The Bragg reflections confirm the hexagonal Wurtzite structure for ZnO. A decrease in crystallite size and an increase in energy band gap were observed for ZnO and ZnO-2DG. The tuning of the band gap plays a vital role in cytotoxicity, arbitrated by intracellular reactive oxygen species. The cytotoxic properties, such as the percentage of inhibition and the percentage of the proliferation of ZnO and ZnO-2DG nanohybrid, are examined against the Kidney cancer Vero cell line and also compared with the standard drugs Levofloxacin and Doxorubicin. Compared to ZnO, ZnO-2DG shows excellent cytotoxic properties, even better than the standard drug against the Vero cell line. Thus, the present ZnO-2DG nanohybrid might be used as a nanodrug and go on to replace Levofloxacin and Doxorubicin as standard drugs in kidney cancer cell therapy.http://www.sciencedirect.com/science/article/pii/S2468217923000564Zinc oxideNanohybridVero cell lineKidney cancer cellCytotoxic |
| spellingShingle | Y.S. Vidya H.C. Manjunatha S. Manjunatha K.N. Sridhar L. Seenappa R. Munirathnam 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment Journal of Science: Advanced Materials and Devices Zinc oxide Nanohybrid Vero cell line Kidney cancer cell Cytotoxic |
| title | 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| title_full | 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| title_fullStr | 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| title_full_unstemmed | 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| title_short | 2-Deoxy-d-glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| title_sort | 2 deoxy d glucose functionalized zinc oxide nanodrug for kidney cancer treatment |
| topic | Zinc oxide Nanohybrid Vero cell line Kidney cancer cell Cytotoxic |
| url | http://www.sciencedirect.com/science/article/pii/S2468217923000564 |
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