Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc clea...

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Bibliographic Details
Main Authors: Laura Pirisinu, Sergio Migliore, Michele Angelo Di Bari, Elena Esposito, Thierry Baron, Claudia D’Agostino, Luigi De Grossi, Gabriele Vaccari, Umberto Agrimi, Romolo Nonno
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2011-04-01
Series:Emerging Infectious Diseases
Subjects:
Prions
transmissible spongiform encephalopathy
scrapie
bovine spongiform encephalopathy
BSE
CH1641
Online Access:https://wwwnc.cdc.gov/eid/article/17/4/10-1215_article
Description
Summary:Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
ISSN:1080-6040
1080-6059

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