Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review
Introduction Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascula...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/3/e065551.full |
| _version_ | 1797857332873396224 |
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| author | Jing Pang José Luis Sánchez-Ramos Gerald F Watts María Elena Mansilla-Rodríguez Manuel J Romero-Jimenez Alina Rigabert Sánchez-Junco Eva Nadiedja Gutierrez-Cortizo Pedro Mata |
| author_facet | Jing Pang José Luis Sánchez-Ramos Gerald F Watts María Elena Mansilla-Rodríguez Manuel J Romero-Jimenez Alina Rigabert Sánchez-Junco Eva Nadiedja Gutierrez-Cortizo Pedro Mata |
| author_sort | Jing Pang |
| collection | DOAJ |
| description | Introduction Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH.Methods and analysis Our literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle–Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case–control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses.Ethics and dissemination All data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences.PROSPERO registration number CRD42022304273. |
| first_indexed | 2024-04-09T20:55:00Z |
| format | Article |
| id | doaj.art-12e9509501dc467286b8954ea4c563e4 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-09T20:55:00Z |
| publishDate | 2023-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-12e9509501dc467286b8954ea4c563e42023-03-29T20:30:06ZengBMJ Publishing GroupBMJ Open2044-60552023-03-0113310.1136/bmjopen-2022-065551Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic reviewJing Pang0José Luis Sánchez-Ramos1Gerald F Watts2María Elena Mansilla-Rodríguez3Manuel J Romero-Jimenez4Alina Rigabert Sánchez-Junco5Eva Nadiedja Gutierrez-Cortizo6Pedro Mata72Cardiometabolic Clinic, Royal Perth Hospital, Perth, Western Australia, AustraliaDepartment of Nursing, University of Huelva, Huelva, SpainCardiometabolic Service, Department of Cardiology and Internal Medicine, Royal Perth Hospital, School of Medicine, University of Western Australia, Perth, Western Australia, AustraliaVascular Risk Unit, Hospital Infanta Elena, Huelva, SpainVascular Risk Unit, Hospital Infanta Elena, Huelva, SpainHospital Juan Ramon Jimenez, Huelva, SpainVascular Risk Unit, Hospital Infanta Elena, Huelva, SpainFundación de Hipercolesterolemia Familiar, Madrid, SpainIntroduction Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH.Methods and analysis Our literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle–Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case–control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses.Ethics and dissemination All data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences.PROSPERO registration number CRD42022304273.https://bmjopen.bmj.com/content/13/3/e065551.full |
| spellingShingle | Jing Pang José Luis Sánchez-Ramos Gerald F Watts María Elena Mansilla-Rodríguez Manuel J Romero-Jimenez Alina Rigabert Sánchez-Junco Eva Nadiedja Gutierrez-Cortizo Pedro Mata Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review BMJ Open |
| title | Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review |
| title_full | Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review |
| title_fullStr | Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review |
| title_full_unstemmed | Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review |
| title_short | Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review |
| title_sort | risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/13/3/e065551.full |
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