Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya
Abstract Introduction Lung cancer has a low overall survival rate linked to late diagnosis and metastasis. Unfortunately, comprehensive data within the African continent are limited due to the lack of a registry, low public awareness of lung cancer, financial constraints, and inadequate screening an...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5658 |
| _version_ | 1797831031609360384 |
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| author | Nur Swaleh Said Amsalu Degu |
| author_facet | Nur Swaleh Said Amsalu Degu |
| author_sort | Nur Swaleh Said |
| collection | DOAJ |
| description | Abstract Introduction Lung cancer has a low overall survival rate linked to late diagnosis and metastasis. Unfortunately, comprehensive data within the African continent are limited due to the lack of a registry, low public awareness of lung cancer, financial constraints, and inadequate screening and treatment facilities. In addition, there was a lack of conclusive data in our setting. Therefore, this study aimed to assess survival outcomes among lung cancer patients at Kenyatta National Hospital. Methods A hospital‐based retrospective cohort study was performed to examine the survival outcomes of 151 lung cancer patients. All eligible lung cancer patients diagnosed and treated in the facility between January 1, 2018, and December 31, 2020, were included. The patients were retrospectively followed from the date of primary cancer diagnosis until death or the last follow‐up period. The Statistical Package for the Social Sciences (SPSS) version 20.0 statistical software was used to enter and analyze the data. Kaplan–Meier survival and Cox regression analysis were employed to determine median survival and predictors of mortality, respectively. Results The mean and median follow‐time was 18.2 and 17.5 months, respectively. Most (98%) of the patients had non‐small cell lung cancer. The 2‐year survival rate was 66.7%, with 59.6% of patients having developed distant metastasis during the follow‐up, while 25.1% were deceased. The median cancer‐specific survival time among the study population was 18.0 ± 3.40 months. Cox regression analyses showed that patients with distant metastasis had five times more risk of dying (AHR: 4.74, 95% CI: 2.1–10.8, p < 0.001) than patients without distant metastasis. Conclusions The overall two‐year survival rate of lung cancer patients at the Kenyatta National Hospital was 66.7%, with most patients developed distant metastasis during the follow‐up period. Distant metastasis was the only significant predictor of mortality among lung cancer patients in our setting. |
| first_indexed | 2024-04-09T13:45:34Z |
| format | Article |
| id | doaj.art-12ea0928d2514bbf9d9b6b409919b2a9 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T13:45:34Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-12ea0928d2514bbf9d9b6b409919b2a92023-05-09T04:04:18ZengWileyCancer Medicine2045-76342023-04-011289194920110.1002/cam4.5658Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in KenyaNur Swaleh Said0Amsalu Degu1Department of Pharmaceutics and Pharmacy Practice School of Pharmacy and Health Sciences, United States International University‐Africa Nairobi KenyaDepartment of Pharmaceutics and Pharmacy Practice School of Pharmacy and Health Sciences, United States International University‐Africa Nairobi KenyaAbstract Introduction Lung cancer has a low overall survival rate linked to late diagnosis and metastasis. Unfortunately, comprehensive data within the African continent are limited due to the lack of a registry, low public awareness of lung cancer, financial constraints, and inadequate screening and treatment facilities. In addition, there was a lack of conclusive data in our setting. Therefore, this study aimed to assess survival outcomes among lung cancer patients at Kenyatta National Hospital. Methods A hospital‐based retrospective cohort study was performed to examine the survival outcomes of 151 lung cancer patients. All eligible lung cancer patients diagnosed and treated in the facility between January 1, 2018, and December 31, 2020, were included. The patients were retrospectively followed from the date of primary cancer diagnosis until death or the last follow‐up period. The Statistical Package for the Social Sciences (SPSS) version 20.0 statistical software was used to enter and analyze the data. Kaplan–Meier survival and Cox regression analysis were employed to determine median survival and predictors of mortality, respectively. Results The mean and median follow‐time was 18.2 and 17.5 months, respectively. Most (98%) of the patients had non‐small cell lung cancer. The 2‐year survival rate was 66.7%, with 59.6% of patients having developed distant metastasis during the follow‐up, while 25.1% were deceased. The median cancer‐specific survival time among the study population was 18.0 ± 3.40 months. Cox regression analyses showed that patients with distant metastasis had five times more risk of dying (AHR: 4.74, 95% CI: 2.1–10.8, p < 0.001) than patients without distant metastasis. Conclusions The overall two‐year survival rate of lung cancer patients at the Kenyatta National Hospital was 66.7%, with most patients developed distant metastasis during the follow‐up period. Distant metastasis was the only significant predictor of mortality among lung cancer patients in our setting.https://doi.org/10.1002/cam4.5658KenyaKenyatta National Hospitallung cancersurvival outcomes |
| spellingShingle | Nur Swaleh Said Amsalu Degu Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya Cancer Medicine Kenya Kenyatta National Hospital lung cancer survival outcomes |
| title | Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya |
| title_full | Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya |
| title_fullStr | Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya |
| title_full_unstemmed | Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya |
| title_short | Assessment of survival outcomes among lung cancer patients at the National and Referral Hospital in Kenya |
| title_sort | assessment of survival outcomes among lung cancer patients at the national and referral hospital in kenya |
| topic | Kenya Kenyatta National Hospital lung cancer survival outcomes |
| url | https://doi.org/10.1002/cam4.5658 |
| work_keys_str_mv | AT nurswalehsaid assessmentofsurvivaloutcomesamonglungcancerpatientsatthenationalandreferralhospitalinkenya AT amsaludegu assessmentofsurvivaloutcomesamonglungcancerpatientsatthenationalandreferralhospitalinkenya |