Role of chemotherapy in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a unique malignant head and neck cancer with clinical, demographic, and geographic features distinct from other head and neck epithelial malignancies. Non-keratinizing, poorly differentiated, and undifferentiated WHO types 2 and 3 is the most common subtypes of NPC....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-06-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/5 |
| _version_ | 1797963824323624960 |
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| author | Fabiola Paiar Vanessa Di Cataldo Giacomo Zei Eleonora Monteleone Pasquetti Sara Cecchini Icro Meattini Monica Mangoni Benedetta Agresti Carmine Iermano Pierluigi Bonomo Giampaolo Biti |
| author_facet | Fabiola Paiar Vanessa Di Cataldo Giacomo Zei Eleonora Monteleone Pasquetti Sara Cecchini Icro Meattini Monica Mangoni Benedetta Agresti Carmine Iermano Pierluigi Bonomo Giampaolo Biti |
| author_sort | Fabiola Paiar |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a unique malignant head and neck cancer with clinical, demographic, and geographic features distinct from other head and neck epithelial malignancies. Non-keratinizing, poorly differentiated, and undifferentiated WHO types 2 and 3 is the most common subtypes of NPC. NPC is also characterized by its relatively high sensitivity to radiation, so that in the last decades radiotherapy (RT) has been the cornerstone of treatment. However, in the majority of cases NPC is discovered at locally advanced stage. The results are disappointing when RT alone is offered. The 5-year survival rates have been reported to be about 34-52%. The poor prognosis for advanced NPC led to increasing interests in exploring the use of chemotherapy (CT). NPC has been considered to be not only radiosensitive but also chemo-sensitive and has shown high response rate to various chemotherapeutic agents. Certainly, the treatment strategies for NPC will continue to change and evolve as a better understanding is gained of the molecular and immune mechanisms that drive this disease. We reviewed the current literature focusing on the role of CT and new-targeted agents. |
| first_indexed | 2024-04-11T01:34:20Z |
| format | Article |
| id | doaj.art-12ead070413743658c76566d7fcdd16f |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:34:20Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-12ead070413743658c76566d7fcdd16f2023-01-03T09:01:29ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652012-06-016110.4081/oncol.2012.e15Role of chemotherapy in nasopharyngeal carcinomaFabiola Paiar0Vanessa Di Cataldo1Giacomo Zei2Eleonora Monteleone Pasquetti3Sara Cecchini4Icro Meattini5Monica Mangoni6Benedetta Agresti7Carmine Iermano8Pierluigi Bonomo9Giampaolo Biti10Radiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, University of Florence, FlorenceRadiotherapy Unit, Casa di Cura S. Chiara, FlorenceRadiotherapy Unit, University of Florence, FlorenceNasopharyngeal carcinoma (NPC) is a unique malignant head and neck cancer with clinical, demographic, and geographic features distinct from other head and neck epithelial malignancies. Non-keratinizing, poorly differentiated, and undifferentiated WHO types 2 and 3 is the most common subtypes of NPC. NPC is also characterized by its relatively high sensitivity to radiation, so that in the last decades radiotherapy (RT) has been the cornerstone of treatment. However, in the majority of cases NPC is discovered at locally advanced stage. The results are disappointing when RT alone is offered. The 5-year survival rates have been reported to be about 34-52%. The poor prognosis for advanced NPC led to increasing interests in exploring the use of chemotherapy (CT). NPC has been considered to be not only radiosensitive but also chemo-sensitive and has shown high response rate to various chemotherapeutic agents. Certainly, the treatment strategies for NPC will continue to change and evolve as a better understanding is gained of the molecular and immune mechanisms that drive this disease. We reviewed the current literature focusing on the role of CT and new-targeted agents.http://www.oncologyreviews.org/index.php/or/article/view/5nasopharyngeal carcinomachemotherapyinduction chemotherapytargeted agents. |
| spellingShingle | Fabiola Paiar Vanessa Di Cataldo Giacomo Zei Eleonora Monteleone Pasquetti Sara Cecchini Icro Meattini Monica Mangoni Benedetta Agresti Carmine Iermano Pierluigi Bonomo Giampaolo Biti Role of chemotherapy in nasopharyngeal carcinoma Oncology Reviews nasopharyngeal carcinoma chemotherapy induction chemotherapy targeted agents. |
| title | Role of chemotherapy in nasopharyngeal carcinoma |
| title_full | Role of chemotherapy in nasopharyngeal carcinoma |
| title_fullStr | Role of chemotherapy in nasopharyngeal carcinoma |
| title_full_unstemmed | Role of chemotherapy in nasopharyngeal carcinoma |
| title_short | Role of chemotherapy in nasopharyngeal carcinoma |
| title_sort | role of chemotherapy in nasopharyngeal carcinoma |
| topic | nasopharyngeal carcinoma chemotherapy induction chemotherapy targeted agents. |
| url | http://www.oncologyreviews.org/index.php/or/article/view/5 |
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