Study on the Antitumor Mechanism of Tanshinone IIA In Vivo and In Vitro through the Regulation of PERK-ATF4-HSPA5 Pathway-Mediated Ferroptosis

Study on the Antitumor Mechanism of Tanshinone IIA In Vivo and In Vitro through the Regulation of PERK-ATF4-HSPA5 Pathway-Mediated Ferroptosis

As a traditional Chinese medicine, <i>Salvia miltiorrhiza Bunge</i> was first recorded in the Shennong Materia Medica Classic and is widely used to treat “the accumulation of symptoms and masses”. The main active ingredient of <i>Salvia miltiorrhiza Bunge</i>, Tanshinone IIA...

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Bibliographic Details
Main Authors: Chunxiang Guo, Wei Zhao, Wei Wang, Zheng Yao, Wenhui Chen, Xiaoyi Feng
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
Tanshinone IIA
endoplasmic reticulum stress
PERK-ATF4-HSPA5 pathway
ferroptosis
anti-hepatoma
Online Access:https://www.mdpi.com/1420-3049/29/7/1557

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