Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Current research focuses on explicitly developing and evaluating nanostructured lipidic carriers (NLCs) for the chemotherapeutic drug Ribociclib (RCB) via the topical route to surmount the inherent bioavailability shortcomings. The absolute oral bioavailability has not been determined, but using a p...

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Bibliographic Details
Main Authors: Mohammed F. Aldawsari, Mohammad Azhar Kamal, Mohamed F. Balaha, Talha Jawaid, Mohammed Jafar, Sana Hashmi, Majid Ahmad Ganaie, Aftab Alam
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Saudi Pharmaceutical Journal
Subjects:
Ribociclib
Nanostructured Lipidic Carriers
BoxBehnken Design
CLSM
Dermatokinetics
Skin cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016424000343

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http://www.sciencedirect.com/science/article/pii/S1319016424000343

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