Subacute sclerosing panencephalitis: A clinical appraisal
Introduction: Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis affecting primarily children and young adults, caused by a persistent infection of immune resistant measles virus. The aim of the present study is to describe the clinical profile and natural history...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=631;epage=633;aulast=Abajirao |
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| author | Sujit Abajirao Abajirao M D Nair Harsha J Kambale |
| author_facet | Sujit Abajirao Abajirao M D Nair Harsha J Kambale |
| author_sort | Sujit Abajirao Abajirao |
| collection | DOAJ |
| description | Introduction: Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis affecting primarily children and young adults, caused by a persistent infection of immune resistant measles virus. The aim of the present study is to describe the clinical profile and natural history of patients with SSPE. Methods: We collected data of patients with SSPE during 2004-2010 who fulfilled Dyken′s criteria. We analyzed demographical, clinical, electrophysiological, and imaging features. Results: Study included 34 patients, 26 (76.5%) males with age of onset from 3 to 31 years. Twenty one patients were below 15 years of age formed childhood SSPE and 13 above 15 years of age constituted adult onset group. 85.3% had low-socioeconomic status. Eleven received measles vaccination and seven were unvaccinated. 59.9% patients had measles history. Most common presenting symptom was scholastic backwardness (52.5%) followed by seizures (23.5%). Three patients each had cortical blindness, macular degeneration, decreased visual acuity, and optic atrophy. Electroencephalographic (EEG) showed long interval periodic complexes and cerebrospinal fluid anti-measles antibody was positive in all. Magnetic resonance imaging was done in 70.5% with was abnormal in 52.5%. Mean incubation period of SSPE after measles was 9.6 years. The follow-up duration was 1-10 years, (average of 2 years). Only one patient died from available data of follow-up, 9 were stable and 10 deteriorated in the form of progression of staging. Conclusion: SSPE is common in low-socioeconomic status. The profile of adult onset did not differ from childhood onset SSPE, except for a longer interval between measles infection and presence of the ophthalmic symptom as presenting feature in adult onset group. |
| first_indexed | 2024-12-21T12:19:03Z |
| format | Article |
| id | doaj.art-12eb25549b4f41e3baa0ca2c6894c98d |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-21T12:19:03Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-12eb25549b4f41e3baa0ca2c6894c98d2022-12-21T19:04:21ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492013-01-0116463163310.4103/0972-2327.120497Subacute sclerosing panencephalitis: A clinical appraisalSujit Abajirao AbajiraoM D NairHarsha J KambaleIntroduction: Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis affecting primarily children and young adults, caused by a persistent infection of immune resistant measles virus. The aim of the present study is to describe the clinical profile and natural history of patients with SSPE. Methods: We collected data of patients with SSPE during 2004-2010 who fulfilled Dyken′s criteria. We analyzed demographical, clinical, electrophysiological, and imaging features. Results: Study included 34 patients, 26 (76.5%) males with age of onset from 3 to 31 years. Twenty one patients were below 15 years of age formed childhood SSPE and 13 above 15 years of age constituted adult onset group. 85.3% had low-socioeconomic status. Eleven received measles vaccination and seven were unvaccinated. 59.9% patients had measles history. Most common presenting symptom was scholastic backwardness (52.5%) followed by seizures (23.5%). Three patients each had cortical blindness, macular degeneration, decreased visual acuity, and optic atrophy. Electroencephalographic (EEG) showed long interval periodic complexes and cerebrospinal fluid anti-measles antibody was positive in all. Magnetic resonance imaging was done in 70.5% with was abnormal in 52.5%. Mean incubation period of SSPE after measles was 9.6 years. The follow-up duration was 1-10 years, (average of 2 years). Only one patient died from available data of follow-up, 9 were stable and 10 deteriorated in the form of progression of staging. Conclusion: SSPE is common in low-socioeconomic status. The profile of adult onset did not differ from childhood onset SSPE, except for a longer interval between measles infection and presence of the ophthalmic symptom as presenting feature in adult onset group.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=631;epage=633;aulast=AbajiraoMeaslesmyoclonussubacute sclerosing panencephalitis |
| spellingShingle | Sujit Abajirao Abajirao M D Nair Harsha J Kambale Subacute sclerosing panencephalitis: A clinical appraisal Annals of Indian Academy of Neurology Measles myoclonus subacute sclerosing panencephalitis |
| title | Subacute sclerosing panencephalitis: A clinical appraisal |
| title_full | Subacute sclerosing panencephalitis: A clinical appraisal |
| title_fullStr | Subacute sclerosing panencephalitis: A clinical appraisal |
| title_full_unstemmed | Subacute sclerosing panencephalitis: A clinical appraisal |
| title_short | Subacute sclerosing panencephalitis: A clinical appraisal |
| title_sort | subacute sclerosing panencephalitis a clinical appraisal |
| topic | Measles myoclonus subacute sclerosing panencephalitis |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=631;epage=633;aulast=Abajirao |
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