Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis
Background: It is well documented that menopause is linked to an increased risk of cardiovascular (CV) events; however, the results of studies focusing on the association between premature ovarian insufficiency (POI) and the risk of CV events are controversial. The aim of this systematic review and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-07-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407193 |
| _version_ | 1797768877738819584 |
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| author | Samira Behboudi-Gandevani Ellen Christin Arntzen Britt Normann Tommy Haugan Razieh Bidhendi-Yarandi |
| author_facet | Samira Behboudi-Gandevani Ellen Christin Arntzen Britt Normann Tommy Haugan Razieh Bidhendi-Yarandi |
| author_sort | Samira Behboudi-Gandevani |
| collection | DOAJ |
| description | Background: It is well documented that menopause is linked to an increased risk of cardiovascular (CV) events; however, the results of studies focusing on the association between premature ovarian insufficiency (POI) and the risk of CV events are controversial. The aim of this systematic review and meta-analysis was to assess the risk of CV events among women with POI compared to women with menopausal aged 50–54 years. Methods: A systematic literature search of PubMed (including Medline), Scopus, and Web of Science was conducted from 1990 to 2022 to retrieve observational studies published in English-language. The studies’ quality was assessed using structured standard tools. Primary-outcome was the pooled risk of the composite outcome of CV events. Results: We included 16 studies involving 40,549 women who suffered from POI and 1,016,633 women as controls. After adjustment for hormone therapy, the pooled risk of composite outcome of CV events and coronary heart disease, among women with the POI was significantly 1.3 (Pooled-adjusted hazard ratio (HR) = 1.35, 95% CI: 1.06–1.63, I2: 0%) and 1.4 (Pooled adjusted HR = 1.42, 95% CI: 1.17–1.66, I2: 0%) fold higher than women with menopausal age 50–54 years. There was no difference between the groups regarding the risk of stroke and death due to CV events between two groups. There was not sufficient data for pooled analysis of other specific CV events. Conclusions: In conclusion, POI is associated with an increased risk of CV events, particularly coronary heart disease. Our findings extend prior work with data supporting POI as a risk-enhancing factor for CV events. However, more studies are needed to confirmed these findings. |
| first_indexed | 2024-03-12T20:59:42Z |
| format | Article |
| id | doaj.art-12eb7b6ee8744e98b64ca29560dc96c8 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-12T20:59:42Z |
| publishDate | 2023-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-12eb7b6ee8744e98b64ca29560dc96c82023-07-31T08:26:15ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-07-0124719310.31083/j.rcm2407193S1530-6550(23)01003-7Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-AnalysisSamira Behboudi-Gandevani0Ellen Christin Arntzen1Britt Normann2Tommy Haugan3Razieh Bidhendi-Yarandi4Faculty of Nursing and Health Sciences, Nord University, 8049 Bodø, NorwayFaculty of Nursing and Health Sciences, Nord University, 8049 Bodø, NorwayFaculty of Nursing and Health Sciences, Nord University, 8049 Bodø, NorwayFaculty of Nursing and Health Sciences, Nord University, 7629 Levanger, NorwayDepartment of Biostatistics, University of Social Welfare and Rehabilitation Sciences, 1985713871 Tehran, IranBackground: It is well documented that menopause is linked to an increased risk of cardiovascular (CV) events; however, the results of studies focusing on the association between premature ovarian insufficiency (POI) and the risk of CV events are controversial. The aim of this systematic review and meta-analysis was to assess the risk of CV events among women with POI compared to women with menopausal aged 50–54 years. Methods: A systematic literature search of PubMed (including Medline), Scopus, and Web of Science was conducted from 1990 to 2022 to retrieve observational studies published in English-language. The studies’ quality was assessed using structured standard tools. Primary-outcome was the pooled risk of the composite outcome of CV events. Results: We included 16 studies involving 40,549 women who suffered from POI and 1,016,633 women as controls. After adjustment for hormone therapy, the pooled risk of composite outcome of CV events and coronary heart disease, among women with the POI was significantly 1.3 (Pooled-adjusted hazard ratio (HR) = 1.35, 95% CI: 1.06–1.63, I2: 0%) and 1.4 (Pooled adjusted HR = 1.42, 95% CI: 1.17–1.66, I2: 0%) fold higher than women with menopausal age 50–54 years. There was no difference between the groups regarding the risk of stroke and death due to CV events between two groups. There was not sufficient data for pooled analysis of other specific CV events. Conclusions: In conclusion, POI is associated with an increased risk of CV events, particularly coronary heart disease. Our findings extend prior work with data supporting POI as a risk-enhancing factor for CV events. However, more studies are needed to confirmed these findings.https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407193cardiovascular eventspremature ovarian insufficiencysystematic review and meta-analysis |
| spellingShingle | Samira Behboudi-Gandevani Ellen Christin Arntzen Britt Normann Tommy Haugan Razieh Bidhendi-Yarandi Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis Reviews in Cardiovascular Medicine cardiovascular events premature ovarian insufficiency systematic review and meta-analysis |
| title | Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis |
| title_full | Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis |
| title_fullStr | Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis |
| title_short | Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis |
| title_sort | cardiovascular events among women with premature ovarian insufficiency a systematic review and meta analysis |
| topic | cardiovascular events premature ovarian insufficiency systematic review and meta-analysis |
| url | https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407193 |
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