The Biology of the Cytolethal Distending Toxins

The Biology of the Cytolethal Distending Toxins

The cytolethal distending toxins (CDTs), produced by a variety of Gram-negative pathogenic bacteria, are the first bacterial genotoxins described, since they cause DNA damage in the target cells. CDT is an A-B2 toxin, where the CdtA and CdtC subunits are required to mediate the binding on the surfac...

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Bibliographic Details
Main Authors: Teresa Frisan, Ximena Cortes-Bratti, Riccardo Guidi, Lina Guerra
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Toxins
Subjects:
cytolethal distending toxin
bacterial genotoxin
toxin internalization
DNA damage
DNA damage response
survival signals
virulence factor
chancroid
periodontitis
colitis/hepatitis
Online Access:http://www.mdpi.com/2072-6651/3/3/172/

Internet

http://www.mdpi.com/2072-6651/3/3/172/

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