The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial
Abstract Objective Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular diseases. This study aimed to assess the effects of soymilk plus probiotics co-administration on cardiovascular risk factors in T2DM patients. Methods One hundred patients with T2DM (aged 40–75 ...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01290-w |
| _version_ | 1811165816226316288 |
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| author | Azimeh Hasanpour Siavash Babajafari Seyed Mohammad Mazloomi Mesbah Shams |
| author_facet | Azimeh Hasanpour Siavash Babajafari Seyed Mohammad Mazloomi Mesbah Shams |
| author_sort | Azimeh Hasanpour |
| collection | DOAJ |
| description | Abstract Objective Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular diseases. This study aimed to assess the effects of soymilk plus probiotics co-administration on cardiovascular risk factors in T2DM patients. Methods One hundred patients with T2DM (aged 40–75 years old) were randomly assigned into 4 groups (soymilk + probiotics supplement, soymilk + placebo, conventional milk + placebo, and probiotics supplement) for 6 weeks. Standard protocols were followed for the collection of fasting blood samples, dietary intakes, and anthropometric measurements. Results It was shown that soymilk + probiotics consumption significantly decreased diastolic blood pressure (DBP) (p = 0.001), triglycerides (TG) (P < 0.001), total cholesterol (TC) (p < 0.01), and insulin (P < 0.003) levels and significantly increased high-density lipoprotein cholesterol (HDL-C) (P = 0.002) levels. Soymilk + placebo administration significantly decreased DBP (p = 0.01), insulin (p = 0.006), and TG (p = 0.001) levels and significantly increased HDL-C (p = 0.03) levels. A significant decrease in insulin (p = 0.003) and systolic blood pressure (SBP) (p = 0.01) levels and an increase in HDL-C (p = 0.04) levels were observed after supplementation with probiotics. Findings from between-group comparisons showed a significant decrease in SBP levels in the probiotics supplement group compared to conventional milk group (p < 0.05). Conclusion Soymilk and probiotics consumption might improve some cardiovascular risk factors in patients with T2DM. However, possible synergic effects while consumption of soymilk plus probiotics supplement didn’t show in this study which warranted further research. |
| first_indexed | 2024-04-10T15:43:49Z |
| format | Article |
| id | doaj.art-12edb3a31ffa4877b7840c6c0ccef714 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-10T15:43:49Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-12edb3a31ffa4877b7840c6c0ccef7142023-02-12T12:14:28ZengBMCBMC Endocrine Disorders1472-68232023-02-0123111010.1186/s12902-023-01290-wThe effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trialAzimeh Hasanpour0Siavash Babajafari1Seyed Mohammad Mazloomi2Mesbah Shams3Department of Nutrition, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical SciencesDepartment of Nutrition, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical SciencesDepartment of Food Hygiene and Quality Control, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical SciencesDepartment of Internal Medicine, Namazi Hospital, Shiraz University of Medical SciencesAbstract Objective Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular diseases. This study aimed to assess the effects of soymilk plus probiotics co-administration on cardiovascular risk factors in T2DM patients. Methods One hundred patients with T2DM (aged 40–75 years old) were randomly assigned into 4 groups (soymilk + probiotics supplement, soymilk + placebo, conventional milk + placebo, and probiotics supplement) for 6 weeks. Standard protocols were followed for the collection of fasting blood samples, dietary intakes, and anthropometric measurements. Results It was shown that soymilk + probiotics consumption significantly decreased diastolic blood pressure (DBP) (p = 0.001), triglycerides (TG) (P < 0.001), total cholesterol (TC) (p < 0.01), and insulin (P < 0.003) levels and significantly increased high-density lipoprotein cholesterol (HDL-C) (P = 0.002) levels. Soymilk + placebo administration significantly decreased DBP (p = 0.01), insulin (p = 0.006), and TG (p = 0.001) levels and significantly increased HDL-C (p = 0.03) levels. A significant decrease in insulin (p = 0.003) and systolic blood pressure (SBP) (p = 0.01) levels and an increase in HDL-C (p = 0.04) levels were observed after supplementation with probiotics. Findings from between-group comparisons showed a significant decrease in SBP levels in the probiotics supplement group compared to conventional milk group (p < 0.05). Conclusion Soymilk and probiotics consumption might improve some cardiovascular risk factors in patients with T2DM. However, possible synergic effects while consumption of soymilk plus probiotics supplement didn’t show in this study which warranted further research.https://doi.org/10.1186/s12902-023-01290-wSoymilkProbioticsType 2 diabetes mellitusT2DMCardiovascular risk factors |
| spellingShingle | Azimeh Hasanpour Siavash Babajafari Seyed Mohammad Mazloomi Mesbah Shams The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial BMC Endocrine Disorders Soymilk Probiotics Type 2 diabetes mellitus T2DM Cardiovascular risk factors |
| title | The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial |
| title_full | The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial |
| title_fullStr | The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial |
| title_full_unstemmed | The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial |
| title_short | The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial |
| title_sort | effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus a randomized clinical trial |
| topic | Soymilk Probiotics Type 2 diabetes mellitus T2DM Cardiovascular risk factors |
| url | https://doi.org/10.1186/s12902-023-01290-w |
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