An intermolecular salt bridge linking substrate binding and P1 substrate specificity switch of arterivirus 3C-like proteases

An intermolecular salt bridge linking substrate binding and P1 substrate specificity switch of arterivirus 3C-like proteases

Equine arteritis virus (EAV) and porcine reproductive and respiratory syndrome virus (PRRSV) represent two members of the family Arteriviridae and pose a major threat to the equine- and swine-breeding industries throughout the world. Previously, we and others demonstrated that PRRSV 3C-like protease...

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Bibliographic Details
Main Authors: Qian Chen, Junwei Zhou, Zhixiang Yang, Jiahui Guo, Zimin Liu, Xinyi Sun, Qingshi Jiang, Liurong Fang, Dang Wang, Shaobo Xiao
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
3C-like protease
Arterivirus
Salt bridge
Molecular dynamics simulation
Substrate specificity switch
Site-directed mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022002732

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