Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs
Succinate, one of the intermediates of the tricarboxylic acid cycle, is now recognized to play a role in a broad range of physiological and pathophysiological settings, but its role in adipogenesis is unclear. Our study used Bama miniature pigs as a model to explore the effects of succinate on perfo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/14/7/999 |
| _version_ | 1827287005096050688 |
|---|---|
| author | Xiangyun Zhai Liping Dang Shiyu Wang Wenyuan Li Chao Sun |
| author_facet | Xiangyun Zhai Liping Dang Shiyu Wang Wenyuan Li Chao Sun |
| author_sort | Xiangyun Zhai |
| collection | DOAJ |
| description | Succinate, one of the intermediates of the tricarboxylic acid cycle, is now recognized to play a role in a broad range of physiological and pathophysiological settings, but its role in adipogenesis is unclear. Our study used Bama miniature pigs as a model to explore the effects of succinate on performance, meat quality, and fat formation. The results showed that adding 1% succinate significantly increased the average daily gain, feed/gain ratio, eye muscle area, and body fat content (<i>p</i> < 0.05), but had no effect on feed intake. Further meat quality analysis showed that succinate increased the marbling score and intramuscular fat content of longissimus dorsi muscle (LM), while decreasing the shear force and the cross-sectional area of LM (<i>p</i> < 0.05). Metabolomics analysis of LM revealed that succinate reshaped levels of fatty acids, triglycerides, glycerophospholipids, and sphingolipids in LM. Succinate promotes adipogenic differentiation in porcine primary preadipocytes. Finally, dietary succinate supplementation increased succinylation modification rather than acetylation modification in the adipose tissue pool. This study elucidated the effects of succinate on the growth and meat quality of pigs and its mechanism of action and provided a reference for the role of succinate in the nutrition and metabolism of pigs. |
| first_indexed | 2024-04-24T10:50:38Z |
| format | Article |
| id | doaj.art-12ef02c6262841e3a240342280a6c104 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-04-24T10:50:38Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-12ef02c6262841e3a240342280a6c1042024-04-12T13:14:05ZengMDPI AGAnimals2076-26152024-03-0114799910.3390/ani14070999Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature PigsXiangyun Zhai0Liping Dang1Shiyu Wang2Wenyuan Li3Chao Sun4College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaAgriculture and Rural Bureau of Yuanyang County, Xinxiang 453000, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaSuccinate, one of the intermediates of the tricarboxylic acid cycle, is now recognized to play a role in a broad range of physiological and pathophysiological settings, but its role in adipogenesis is unclear. Our study used Bama miniature pigs as a model to explore the effects of succinate on performance, meat quality, and fat formation. The results showed that adding 1% succinate significantly increased the average daily gain, feed/gain ratio, eye muscle area, and body fat content (<i>p</i> < 0.05), but had no effect on feed intake. Further meat quality analysis showed that succinate increased the marbling score and intramuscular fat content of longissimus dorsi muscle (LM), while decreasing the shear force and the cross-sectional area of LM (<i>p</i> < 0.05). Metabolomics analysis of LM revealed that succinate reshaped levels of fatty acids, triglycerides, glycerophospholipids, and sphingolipids in LM. Succinate promotes adipogenic differentiation in porcine primary preadipocytes. Finally, dietary succinate supplementation increased succinylation modification rather than acetylation modification in the adipose tissue pool. This study elucidated the effects of succinate on the growth and meat quality of pigs and its mechanism of action and provided a reference for the role of succinate in the nutrition and metabolism of pigs.https://www.mdpi.com/2076-2615/14/7/999Bama miniature pigssuccinatelipid depositionmeat quality |
| spellingShingle | Xiangyun Zhai Liping Dang Shiyu Wang Wenyuan Li Chao Sun Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs Animals Bama miniature pigs succinate lipid deposition meat quality |
| title | Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs |
| title_full | Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs |
| title_fullStr | Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs |
| title_full_unstemmed | Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs |
| title_short | Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs |
| title_sort | effects of succinate on growth performance meat quality and lipid synthesis in bama miniature pigs |
| topic | Bama miniature pigs succinate lipid deposition meat quality |
| url | https://www.mdpi.com/2076-2615/14/7/999 |
| work_keys_str_mv | AT xiangyunzhai effectsofsuccinateongrowthperformancemeatqualityandlipidsynthesisinbamaminiaturepigs AT lipingdang effectsofsuccinateongrowthperformancemeatqualityandlipidsynthesisinbamaminiaturepigs AT shiyuwang effectsofsuccinateongrowthperformancemeatqualityandlipidsynthesisinbamaminiaturepigs AT wenyuanli effectsofsuccinateongrowthperformancemeatqualityandlipidsynthesisinbamaminiaturepigs AT chaosun effectsofsuccinateongrowthperformancemeatqualityandlipidsynthesisinbamaminiaturepigs |