The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials
Abstract Objective Guizhi Fuling Capsule (GZFL), a classic traditional Chinese medicine prescription, is often recommended for the treatment of uterine fibroids (UFs). However, the efficacy and safety of GZFL in combination with low-dose mifepristone (MFP) remains controversial. Materials and method...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Complementary Medicine and Therapies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12906-023-03842-y |
| _version_ | 1797865583335702528 |
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| author | Yiming Lei Lili Yang Honglian Yang Min Li Li Ou Yang Bai Taiwei Dong Feng Gao Peifeng Wei |
| author_facet | Yiming Lei Lili Yang Honglian Yang Min Li Li Ou Yang Bai Taiwei Dong Feng Gao Peifeng Wei |
| author_sort | Yiming Lei |
| collection | DOAJ |
| description | Abstract Objective Guizhi Fuling Capsule (GZFL), a classic traditional Chinese medicine prescription, is often recommended for the treatment of uterine fibroids (UFs). However, the efficacy and safety of GZFL in combination with low-dose mifepristone (MFP) remains controversial. Materials and methods We searched eight literature databases and two clinical trial registries for randomized controlled trials (RCTs) of the efficacy and safety of GZFL combined with low-dose MFP in the treatment of UFs from database inception to April 24, 2022. Data analysis was performed using the Meta package in RStudio and RevMan 5.4. GRADE pro3.6.1 software was used for the assessment of evidence quality. Results Twenty-eight RCTs were included in this study, including a total of 2813 patients. The meta-analysis showed that compared with low-dose MFP alone, GZFL combined with low-dose MFP significantly reduced follicle stimulating hormone (p < 0.001), estradiol (p < 0.001), progesterone (p < 0.001), luteinizing hormone (p < 0.001), uterine fibroids volume (p < 0.001), uterine volume (p < 0.001), menstrual flow (p < 0.001) and increased clinical efficiency rate (p < 0.001). Meanwhile, GZFL combined with low-dose MFP did not significantly increase the incidence of adverse drug reactions compared with low-dose MFP alone (p = 0.16). The quality of the evidence for the outcomes ranged from “very low” to “moderate.” Conclusion This study suggests that GZFL combined with low-dose MFP is more effective and safe in the treatment of UFs, and it is a potential treatment for UFs. However, due to the poor quality of the included RCTs formulations, we recommend a rigorous, high-quality, large-sample trial to confirm our findings. |
| first_indexed | 2024-04-09T23:10:28Z |
| format | Article |
| id | doaj.art-12f2beae405b46cb8bab7f7e9fd5c3f3 |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-04-09T23:10:28Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-12f2beae405b46cb8bab7f7e9fd5c3f32023-03-22T10:24:25ZengBMCBMC Complementary Medicine and Therapies2662-76712023-02-0123112010.1186/s12906-023-03842-yThe efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trialsYiming Lei0Lili Yang1Honglian Yang2Min Li3Li Ou4Yang Bai5Taiwei Dong6Feng Gao7Peifeng Wei8Shaanxi University of Chinese MedicineShaanxi University of Chinese MedicineThe Second Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxi University of Chinese MedicineShaanxi University of Chinese MedicineThe Second Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxi University of Chinese MedicineShaanxi University of Chinese MedicineThe Second Affiliated Hospital of Shaanxi University of Chinese MedicineAbstract Objective Guizhi Fuling Capsule (GZFL), a classic traditional Chinese medicine prescription, is often recommended for the treatment of uterine fibroids (UFs). However, the efficacy and safety of GZFL in combination with low-dose mifepristone (MFP) remains controversial. Materials and methods We searched eight literature databases and two clinical trial registries for randomized controlled trials (RCTs) of the efficacy and safety of GZFL combined with low-dose MFP in the treatment of UFs from database inception to April 24, 2022. Data analysis was performed using the Meta package in RStudio and RevMan 5.4. GRADE pro3.6.1 software was used for the assessment of evidence quality. Results Twenty-eight RCTs were included in this study, including a total of 2813 patients. The meta-analysis showed that compared with low-dose MFP alone, GZFL combined with low-dose MFP significantly reduced follicle stimulating hormone (p < 0.001), estradiol (p < 0.001), progesterone (p < 0.001), luteinizing hormone (p < 0.001), uterine fibroids volume (p < 0.001), uterine volume (p < 0.001), menstrual flow (p < 0.001) and increased clinical efficiency rate (p < 0.001). Meanwhile, GZFL combined with low-dose MFP did not significantly increase the incidence of adverse drug reactions compared with low-dose MFP alone (p = 0.16). The quality of the evidence for the outcomes ranged from “very low” to “moderate.” Conclusion This study suggests that GZFL combined with low-dose MFP is more effective and safe in the treatment of UFs, and it is a potential treatment for UFs. However, due to the poor quality of the included RCTs formulations, we recommend a rigorous, high-quality, large-sample trial to confirm our findings.https://doi.org/10.1186/s12906-023-03842-yGuizhi Fuling capsuleUterine fibroidsMifepristoneSystematic reviewMeta-analysis |
| spellingShingle | Yiming Lei Lili Yang Honglian Yang Min Li Li Ou Yang Bai Taiwei Dong Feng Gao Peifeng Wei The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials BMC Complementary Medicine and Therapies Guizhi Fuling capsule Uterine fibroids Mifepristone Systematic review Meta-analysis |
| title | The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials |
| title_full | The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials |
| title_fullStr | The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials |
| title_full_unstemmed | The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials |
| title_short | The efficacy and safety of Chinese herbal medicine Guizhi Fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials |
| title_sort | efficacy and safety of chinese herbal medicine guizhi fuling capsule combined with low dose mifepristone in the treatment of uterine fibroids a systematic review and meta analysis of 28 randomized controlled trials |
| topic | Guizhi Fuling capsule Uterine fibroids Mifepristone Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12906-023-03842-y |
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