Experimental diabetic nephropathy in rats injected with alloxan
The present investigation aimed determenation of diabetic nephrepathy in alloxan treated rats. The study included: • Seruim chemical studies. • Histopathological and histochemical study on the kidney glomeruli. Thirty white male rats were used. They were randomly allocated into 3 gro...
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| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad, College of Veterinary Medicine
1996-06-01
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| Series: | The Iraqi Journal of Veterinary Medicine |
| Subjects: | |
| Online Access: | https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1588 |
| _version_ | 1827764944231202816 |
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| author | Bushra Ibrahim Mustafa |
| author_facet | Bushra Ibrahim Mustafa |
| author_sort | Bushra Ibrahim Mustafa |
| collection | DOAJ |
| description |
The present investigation aimed determenation of diabetic nephrepathy in alloxan treated rats. The study included:
• Seruim chemical studies.
• Histopathological and histochemical study on the kidney glomeruli.
Thirty white male rats were used. They were randomly allocated into 3 groups. Izgroup was injected with alloxan monohydrate for 30 days:
2nd group was fed 1% cholesterd lie and injection of 38 mg/kg B.W alloxan dialy for 30 days; 3rd group was normal diet.
kept on
Blood glucose and total Serum cholestered in 1 and 2 groups significantly increased at day 10, 20, 30.
Glomerular lesion in 1 and 2 groups were found, characterized by dilation of glomeruli which showed lipid accumulation.
In conclusion, hyperlipidemia accompanying hyperlipidemia in alloxan induced hyperglycemia, in part apossible factor in the pathogenesis of diabetic nephropathy.
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| first_indexed | 2024-03-11T11:12:09Z |
| format | Article |
| id | doaj.art-12f350b7e8534d4db2f582f96127d541 |
| institution | Directory Open Access Journal |
| issn | 1609-5693 2410-7409 |
| language | English |
| last_indexed | 2024-03-11T11:12:09Z |
| publishDate | 1996-06-01 |
| publisher | University of Baghdad, College of Veterinary Medicine |
| record_format | Article |
| series | The Iraqi Journal of Veterinary Medicine |
| spelling | doaj.art-12f350b7e8534d4db2f582f96127d5412023-11-11T13:48:20ZengUniversity of Baghdad, College of Veterinary MedicineThe Iraqi Journal of Veterinary Medicine1609-56932410-74091996-06-0120110.30539/ijvm.v20i1.1588Experimental diabetic nephropathy in rats injected with alloxanBushra Ibrahim Mustafa0College of Vet.Medicine Baghdad University The present investigation aimed determenation of diabetic nephrepathy in alloxan treated rats. The study included: • Seruim chemical studies. • Histopathological and histochemical study on the kidney glomeruli. Thirty white male rats were used. They were randomly allocated into 3 groups. Izgroup was injected with alloxan monohydrate for 30 days: 2nd group was fed 1% cholesterd lie and injection of 38 mg/kg B.W alloxan dialy for 30 days; 3rd group was normal diet. kept on Blood glucose and total Serum cholestered in 1 and 2 groups significantly increased at day 10, 20, 30. Glomerular lesion in 1 and 2 groups were found, characterized by dilation of glomeruli which showed lipid accumulation. In conclusion, hyperlipidemia accompanying hyperlipidemia in alloxan induced hyperglycemia, in part apossible factor in the pathogenesis of diabetic nephropathy. https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1588ratsalloxandiabetic |
| spellingShingle | Bushra Ibrahim Mustafa Experimental diabetic nephropathy in rats injected with alloxan The Iraqi Journal of Veterinary Medicine rats alloxan diabetic |
| title | Experimental diabetic nephropathy in rats injected with alloxan |
| title_full | Experimental diabetic nephropathy in rats injected with alloxan |
| title_fullStr | Experimental diabetic nephropathy in rats injected with alloxan |
| title_full_unstemmed | Experimental diabetic nephropathy in rats injected with alloxan |
| title_short | Experimental diabetic nephropathy in rats injected with alloxan |
| title_sort | experimental diabetic nephropathy in rats injected with alloxan |
| topic | rats alloxan diabetic |
| url | https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1588 |
| work_keys_str_mv | AT bushraibrahimmustafa experimentaldiabeticnephropathyinratsinjectedwithalloxan |